Health Dictionary
Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
Renal amyloidosis other diagnostic studies
Introduction
Overview
Overview
Kidney biopsy can represent amyloid deposition as vascular, tubulo-interstitial and/or glomerular deposits. All types of amyloidogenic proteins show affinity for Congo red dye.
Other Diagnostic Studies
Other Diagnostic Studies
Kidney biopsy
- Kidney biopsy can represent amyloid deposition as vascular, tubulo-interstitial and/or glomerular deposits.[1]
- In evaluation of kidney biopsy specimens, types of amyloidogenic proteins can be discovered.[2]
Congo red staining
- All types of amyloidogenic proteins show affinity for Congo red dye, which demonstrates as:[3]
- Orange-red appearance by normal light microscopy
- Apple-green birefringence upon polarized light
References
References
- ↑ von Hutten H, Mihatsch M, Lobeck H, Rudolph B, Eriksson M, Röcken C (August 2009). “Prevalence and origin of amyloid in kidney biopsies”. Am. J. Surg. Pathol. 33 (8): 1198–205. doi:10.1097/PAS.0b013e3181abdfa7. PMID 19561448.
- ↑ Khalighi MA, Dean Wallace W, Palma-Diaz MF (April 2014). “Amyloid nephropathy”. Clin Kidney J. 7 (2): 97–106. doi:10.1093/ckj/sfu021. PMC 4377792. PMID 25852856.
- ↑ Khalighi MA, Dean Wallace W, Palma-Diaz MF (April 2014). “Amyloid nephropathy”. Clin Kidney J. 7 (2): 97–106. doi:10.1093/ckj/sfu021. PMC 4377792. PMID 25852856.
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Shaghayegh Habibi, M.D.[2]