Renal amyloidosis other diagnostic studies

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Shaghayegh Habibi, M.D.[2]

Overview

Kidney biopsy can represent amyloid deposition as vascular, tubulo-interstitial and/or glomerular deposits. All types of amyloidogenic proteins show affinity for Congo red dye.

Other Diagnostic Studies

Kidney biopsy

Kidney biopsy can represent amyloid deposition as vascular, tubulo-interstitial and/or glomerular deposits.^[1]
In evaluation of kidney biopsy specimens, types of amyloidogenic proteins can be discovered.^[2]

Congo red staining

All types of amyloidogenic proteins show affinity for Congo red dye, which demonstrates as:^[3]
- Orange-red appearance by normal light microscopy
- Apple-green birefringence upon polarized light

References

↑ von Hutten H, Mihatsch M, Lobeck H, Rudolph B, Eriksson M, Röcken C (August 2009). “Prevalence and origin of amyloid in kidney biopsies”. Am. J. Surg. Pathol. 33 (8): 1198–205. doi:10.1097/PAS.0b013e3181abdfa7. PMID 19561448.
↑ Khalighi MA, Dean Wallace W, Palma-Diaz MF (April 2014). “Amyloid nephropathy”. Clin Kidney J. 7 (2): 97–106. doi:10.1093/ckj/sfu021. PMC 4377792. PMID 25852856.
↑ Khalighi MA, Dean Wallace W, Palma-Diaz MF (April 2014). “Amyloid nephropathy”. Clin Kidney J. 7 (2): 97–106. doi:10.1093/ckj/sfu021. PMC 4377792. PMID 25852856.

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[pmid19561448-1] von Hutten H, Mihatsch M, Lobeck H, Rudolph B, Eriksson M, Röcken C (August 2009). “Prevalence and origin of amyloid in kidney biopsies”. Am. J. Surg. Pathol. 33 (8): 1198–205. doi:10.1097/PAS.0b013e3181abdfa7. PMID 19561448.

[pmid25852856-2] Khalighi MA, Dean Wallace W, Palma-Diaz MF (April 2014). “Amyloid nephropathy”. Clin Kidney J. 7 (2): 97–106. doi:10.1093/ckj/sfu021. PMC 4377792. PMID 25852856.

[pmid258528562-3] Khalighi MA, Dean Wallace W, Palma-Diaz MF (April 2014). “Amyloid nephropathy”. Clin Kidney J. 7 (2): 97–106. doi:10.1093/ckj/sfu021. PMC 4377792. PMID 25852856.

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