Health Dictionary
Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
Renal amyloidosis risk factors
Introduction
Overview
Overview
Common risk factors in the development of renal amyloidosis include genetic mutations such as heterozygous mutations in the genes for lysozyme, apolipoprotein AI, apolipoprotein AII, or fibrinogen A alpha-chain.
Risk Factors
Risk Factors
The most potent risk factor in the development of renal amyloidosis are genetic mutations which include:[1][2]
- SAA1 gene mutaions
- Point mutations in the apoAI gene
- Point mutations in the apoAII gene
- Heterozygous mutations in the genes for lysozyme, apolipoprotein AI, apolipoprotein AII,, or fibrinogen A alpha-chain
References
References
- ↑ Obici L, Raimondi S, Lavatelli F, Bellotti V, Merlini G (October 2009). “Susceptibility to AA amyloidosis in rheumatic diseases: a critical overview”. Arthritis Rheum. 61 (10): 1435–40. doi:10.1002/art.24735. PMID 19790131.
- ↑ Booth DR, Booth SE, Gillmore JD, Hawkins PN, Pepys MB (December 1998). “SAA1 alleles as risk factors in reactive systemic AA amyloidosis”. Amyloid. 5 (4): 262–5. PMID 10036584.
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Omer Kamal, M.D. [2]