Renal papillary necrosis historical Perspective

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Nasrin Nikravangolsefid, MD-MPH [2]

Overview

Renal papillary necrosis was first introduced by Friedrich in 1877, following urinary obstruction. Then, other associated factors such as diabetes, sickle cell disease and analgesics were found.

Discovery

Renal papillary necrosis was first discovered by professor Friedrich in 1877, in a patient following urinary obstruction due to prostatic hyperplasia. ^[1]
Gunther and Edmonson found association between RPN and diabetes mellitus. ^[2]

Analgesic nephropathy was first described by Spuhler and Zollinger in 1953 due to chronic use of pain killer medications containing phenacetin. ^[3]
The association between RPN and sickle cell disease was found by Sydenstricker in 1923. ^[2]

Landmark Events in the Development of Treatment Strategies

Impact on Cultural History

Famous Cases

References

↑ Friedreich, N. (1877). “Ueber Necrose der Nierenpapillen bei Hydronephrose”. Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin. 69 (2): 308–312. doi:10.1007/BF02326121. ISSN 0945-6317.
↑ ^2.0 ^2.1 Madu AJ, Okoye AE, Ajuba IC, Madu KA, Anigbo C, Agu K (2016). “Prevalence and associations of symptomatic renal papillary necrosis in sickle cell anemia patients in South-Eastern Nigeria”. Niger J Clin Pract. 19 (4): 471–4. doi:10.4103/1119-3077.183299. PMID 27251962.
↑ SPUHLER O, ZOLLINGER HU (1953). “[Chronic interstitial nephritis]”. Z Klin Med. 151 (1): 1–50. PMID 13137299.

Overview