Reticulum cell sarcoma pathophysiology

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Pathophysiology

The dominant cell type is thought to be derived from histiocytes or macrophages. More recent thinking indicates that this cancer may arise from lymphocytes or immunoblasts.

Large, foam filled histiocytes with numerous mitoses and scant stroma are present
Stains for reticulum are positive
Periodic Acid Schiff (PAS) stains are negative

References

Overview