Retroperitoneal fibrosis

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Retroperitoneal fibrosis or Ormond’s disease is a disease featuring the proliferation of fibrous tissue in the retroperitoneum, the compartment of the body containing the kidneys, aorta, renal tract and various other structures. It may present with lower back pain, renal failure, hypertension, deep vein thrombosis and other obstructive symptoms.

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Its association with various immune-related conditions and response to immunosuppression have led to speculations as to the autoimmune etiology of idiopathic RPF. One-third of the cases are secondary to malignancy, medication (methysergide, hydralazine, beta blockers), aortic aneurysm or certain infections.

Life-threatening causes include conditions which may result in death or permanent disability within 24 hours if left untreated.

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

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The disorder may lead to:

• Chronic bilateral obstructive uropathy
• Chronic kidney failure
• Chronic unilateral obstructive uropathy

Prognosis depends on the extent of the fibrosis and the amount of damage to the kidneys. The kidney damage may be temporary or permanent.

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