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Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.

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Roseola historical perspective

Introduction

Overview

Overview

For the first time, Zahorsky of St. Louis in 1910 described a febrile exanthem occurring in infants which he termed roseola. Human herpes virus 6 was first identified in 1986.

Historical Perspective

Historical Perspective

  • For the first time, Zahorsky of St. Louis in 1910 described a febrile exanthem occurring in infants which he termed roseola.
  • In 1986, Human herpes virus 6 (HHV6), the main causative agent of roseola disease was first isolated from patients who were diagnosed with HIV AIDS or a lymphoproliferative disorder from the peripheral blood leukocytes. [1]
  • The two different variants of HHV 6 discovered by Frenkel, Ablashi and Aubin are variant A and Variant B HHV 6 strains.[2][3][4]
  • HHV 6A has been found to be more associated with the development of roseola.
References

References

  1. ↑ Salahuddin SZ, Ablashi DV, Markham PD, Josephs SF, Sturzenegger S, Kaplan M; et al. (1986). “Isolation of a new virus, HBLV, in patients with lymphoproliferative disorders”. Science. 234 (4776): 596–601. PMID 2876520.
  2. ↑ Schirmer EC, Wyatt LS, Yamanishi K, Rodriguez WJ, Frenkel N (1991). “Differentiation between two distinct classes of viruses now classified as human herpesvirus 6”. Proc Natl Acad Sci U S A. 88 (13): 5922–6. PMC 51990. PMID 1648234.
  3. ↑ Ablashi DV, Balachandran N, Josephs SF, Hung CL, Krueger GR, Kramarsky B; et al. (1991). “Genomic polymorphism, growth properties, and immunologic variations in human herpesvirus-6 isolates”. Virology. 184 (2): 545–52. PMID 1653487.
  4. ↑ Aubin JT, Collandre H, Candotti D, Ingrand D, Rouzioux C, Burgard M; et al. (1991). “Several groups among human herpesvirus 6 strains can be distinguished by Southern blotting and polymerase chain reaction”. J Clin Microbiol. 29 (2): 367–72. PMC 269769. PMID 1848868.

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Omodamola Aje B.Sc, M.D. [2]