Roseola history and symptoms

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Omodamola Aje B.Sc, M.D. [2]

Overview

The hallmark of roseola is a non-pruritic macular or maculopapular rash. A positive history of a high fever of 40ºC (104ºF) that lasts for 3 to 5 days.^[1]

History and symptoms

The hallmark of roseola is a non-pruritic macular or maculopapular rash. A positive history of a high fever of 40ºC (104ºF) that lasts for 3 to 5 days.^[2]^[3]

Common symptoms

High fever 40ºC (104ºF)
Rash

Less common symptoms

Irritability in infants and children
Mild diarrhea
Decreased appetite
Swollen eyelids
Injection of the tympanic membrane
Cervical or occipital lymphadenopathy
Red papules on the soft palate may be seen (Nagayama’s spots)
Uvulo-palatoglossal junction ulcers
Bulging fontanelles

References

↑ Agut H, Bonnafous P, Gautheret-Dejean A (2015). “Laboratory and clinical aspects of human herpesvirus 6 infections”. Clin Microbiol Rev. 28 (2): 313–35. doi:10.1128/CMR.00122-14. PMC 4402955. PMID 25762531.
↑ Pruksananonda P, Hall CB, Insel RA, McIntyre K, Pellett PE, Long CE; et al. (1992). “Primary human herpesvirus 6 infection in young children”. N Engl J Med. 326 (22): 1445–50. doi:10.1056/NEJM199205283262201. PMID 1315416.
↑ Asano Y, Yoshikawa T, Suga S, Kobayashi I, Nakashima T, Yazaki T; et al. (1994). “Clinical features of infants with primary human herpesvirus 6 infection (exanthem subitum, roseola infantum)”. Pediatrics. 93 (1): 104–8. PMID 8265302.

[pmid25762531-1] Agut H, Bonnafous P, Gautheret-Dejean A (2015). “Laboratory and clinical aspects of human herpesvirus 6 infections”. Clin Microbiol Rev. 28 (2): 313–35. doi:10.1128/CMR.00122-14. PMC 4402955. PMID 25762531.

[pmid1315416-2] Pruksananonda P, Hall CB, Insel RA, McIntyre K, Pellett PE, Long CE; et al. (1992). “Primary human herpesvirus 6 infection in young children”. N Engl J Med. 326 (22): 1445–50. doi:10.1056/NEJM199205283262201. PMID 1315416.

[pmid8265302-3] Asano Y, Yoshikawa T, Suga S, Kobayashi I, Nakashima T, Yazaki T; et al. (1994). “Clinical features of infants with primary human herpesvirus 6 infection (exanthem subitum, roseola infantum)”. Pediatrics. 93 (1): 104–8. PMID 8265302.

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