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S-adenosylhomocysteine hydrolase

Introduction

Adenosylhomocysteinase (EC 3.3.1.1, S-adenosylhomocysteine synthase, S-adenosylhomocysteine hydrolase, adenosylhomocysteine hydrolase, S-adenosylhomocysteinase, SAHase, AdoHcyase) is an enzyme that converts S-adenosylhomocysteine to homocysteine and adenosine.[1][2] This enzyme catalyses the following chemical reaction

S-adenosyl-L-homocysteine + H2O ⇌ L–homocysteine + adenosine

The enzyme contains one tightly bound NAD+ per subunit.

References

References

  1. ↑ De La Haba G, Cantoni GL (March 1959). “The enzymatic synthesis of S-adenosyl-L-homocysteine from adenosine and homocysteine”. The Journal of Biological Chemistry. 234 (3): 603–8. PMID 13641268.
  2. ↑ Palmer JL, Abeles RH (February 1979). “The mechanism of action of S-adenosylhomocysteinase”. The Journal of Biological Chemistry. 254 (4): 1217–26. PMID 762125.
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