SCEL (gene)
Sciellin is a protein that in humans is encoded by the SCEL gene.[1][2]
The protein encoded by this gene is a precursor to the cornified envelope of terminally differentiated keratinocytes. This protein localizes to the periphery of cells and may function in the assembly or regulation of proteins in the cornified envelope. Transcript variants encoding different isoforms exist. A transcript variant utilizing an alternative polyA signal has been described in the literature, but its full-length nature has not been determined.[2]
References
References
- ↑ Champliaud MF, Burgeson RE, Jin W, Baden HP, Olson PF (Dec 1998). “cDNA cloning and characterization of sciellin, a LIM domain protein of the keratinocyte cornified envelope”. J Biol Chem. 273 (47): 31547–54. doi:10.1074/jbc.273.47.31547. PMID 9813070.
- ↑ 2.0 2.1 “Entrez Gene: SCEL sciellin”.
Further reading
Further reading
- Corona W, Karkera DJ, Patterson RH, et al. (2004). “Analysis of Sciellin (SCEL) as a candidate gene in esophageal squamous cell carcinoma”. Anticancer Res. 24 (3a): 1417–9. PMID 15274303.
- Champliaud MF, Viel A, Baden HP (2003). “The expression of vitamin D-upregulated protein 1 in skin and its interaction with sciellin in cultured keratinocytes”. J. Invest. Dermatol. 121 (4): 781–5. doi:10.1046/j.1523-1747.2003.12539.x. PMID 14632196.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). “Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Champliaud MF, Baden HP, Koch M, et al. (2001). “Gene characterization of sciellin (SCEL) and protein localization in vertebrate epithelia displaying barrier properties”. Genomics. 70 (2): 264–8. doi:10.1006/geno.2000.6390. PMID 11112355.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). “Construction and characterization of a full length-enriched and a 5′-end-enriched cDNA library”. Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- Maruyama K, Sugano S (1994). “Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides”. Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- Kvedar JC, Manabe M, Phillips SB, et al. (1992). “Characterization of sciellin, a precursor to the cornified envelope of human keratinocytes”. Differentiation. 49 (3): 195–204. doi:10.1111/j.1432-0436.1992.tb00667.x. PMID 1377656.
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