Health Dictionary
Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
SDK1
Introduction
Sidekick cell adhesion molecule 1 is a protein that in humans is encoded by the SDK1 gene. [1]
Function
Function
The protein encoded by this gene is a member of the immunoglobulin superfamily. The protein contains six immunoglobulin-like domains and thirteen fibronectin type III domains. Fibronectin type III domains are present in both extracellular and intracellular proteins and tandem repeats are known to contain binding sites for DNA, heparin and the cell surface. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2016].
Further reading
Further reading
- Kaufman L, Hayashi K, Ross MJ, Ross MD, Klotman PE (July 2004). “Sidekick-1 is upregulated in glomeruli in HIV-associated nephropathy”. J. Am. Soc. Nephrol. 15 (7): 1721–30. PMID 15213259.
- Oguri M, Kato K, Yokoi K, Yoshida T, Watanabe S, Metoki N, Yoshida H, Satoh K, Aoyagi Y, Nozawa Y, Yamada Y (January 2010). “Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals”. Am. J. Hypertens. 23 (1): 70–7. doi:10.1038/ajh.2009.190. PMID 19851296.
- Oguri M, Kato K, Yokoi K, Yoshida T, Watanabe S, Metoki N, Yoshida H, Satoh K, Aoyagi Y, Nozawa Y, Yamada Y (January 2010). “Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals”. Am. J. Hypertens. 23 (1): 70–7. doi:10.1038/ajh.2009.190. PMID 19851296.
- Yoshida T, Kato K, Yokoi K, Oguri M, Watanabe S, Metoki N, Yoshida H, Satoh K, Aoyagi Y, Nozawa Y, Yamada Y (April 2010). “Association of genetic variants with hemorrhagic stroke in Japanese individuals”. Int. J. Mol. Med. 25 (4): 649–56. PMID 20198315.
- Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR (2010). “Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score”. Mol. Med. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464. PMID 20379614.
- Saus E, Brunet A, Armengol L, Alonso P, Crespo JM, Fernández-Aranda F, Guitart M, MartÃn-Santos R, Menchón JM, Navinés R, Soria V, Torrens M, Urretavizcaya M, Vallès V, Gratacòs M, Estivill X (October 2010). “Comprehensive copy number variant (CNV) analysis of neuronal pathways genes in psychiatric disorders identifies rare variants within patients”. J Psychiatr Res. 44 (14): 971–8. doi:10.1016/j.jpsychires.2010.03.007. PMID 20398908.
- Kaufman L, Potla U, Coleman S, Dikiy S, Hata Y, Kurihara H, He JC, D’Agati VD, Klotman PE (August 2010). “Up-regulation of the homophilic adhesion molecule sidekick-1 in podocytes contributes to glomerulosclerosis”. J. Biol. Chem. 285 (33): 25677–85. doi:10.1074/jbc.M110.133959. PMC 2919131. PMID 20562105.
- Cadby G, Mukherjee S, Musk AW, Reid A, Garlepp M, Dick I, Robinson C, Hui J, Fiorito G, Guarrera S, Beilby J, Melton PE, Moses EK, Ugolini D, Mirabelli D, Bonassi S, Magnani C, Dianzani I, Matullo G, Robinson B, Creaney J, Palmer LJ (October 2013). “A genome-wide association study for malignant mesothelioma risk”. Lung Cancer. 82 (1): 1–8. doi:10.1016/j.lungcan.2013.04.018. PMID 23827383.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.