SESN3
Sestrin 3 is a protein that in humans is encoded by the SESN3 gene. [1]
Function
Function
This gene encodes a member of the sestrin family of stress-induced proteins. The encoded protein reduces the levels of intracellular reactive oxygen species induced by activated Ras downstream of RAC-alpha serine/threonine-protein kinase (Akt) and FoxO transcription factor. The protein is required for normal regulation of blood glucose, insulin resistance and plays a role in lipid storage in obesity. Alternative splicing results in multiple transcript variants.
Further reading
Further reading
- Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR (2010). “Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score”. Mol. Med. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464. PMID 20379614.
- Chen CC, Jeon SM, Bhaskar PT, Nogueira V, Sundararajan D, Tonic I, Park Y, Hay N (2010). “FoxOs inhibit mTORC1 and activate Akt by inducing the expression of Sestrin3 and Rictor”. Dev. Cell. 18 (4): 592–604. doi:10.1016/j.devcel.2010.03.008. PMC 3031984. PMID 20412774.
- Zamkova M, Khromova N, Kopnin BP, Kopnin P (2013). “Ras-induced ROS upregulation affecting cell proliferation is connected with cell type-specific alterations of HSF1/SESN3/p21Cip1/WAF1 pathways”. Cell Cycle. 12 (5): 826–36. doi:10.4161/cc.23723. PMC 3610730. PMID 23388456.
- Nascimento EB, Osler ME, Zierath JR (2013). “Sestrin 3 regulation in type 2 diabetic patients and its influence on metabolism and differentiation in skeletal muscle”. Am. J. Physiol. Endocrinol. Metab. 305 (11): E1408–14. doi:10.1152/ajpendo.00212.2013. PMC 3882372. PMID 24129397.
- Vakana E, Arslan AD, Szilard A, Altman JK, Platanias LC (2013). “Regulatory effects of sestrin 3 (SESN3) in BCR-ABL expressing cells”. PLoS ONE. 8 (11): e78780. doi:10.1371/journal.pone.0078780. PMC 3832611. PMID 24260131.
- Kang X, Petyaykina K, Tao R, Xiong X, Dong XC, Liangpunsakul S (2014). “The inhibitory effect of ethanol on Sestrin3 in the pathogenesis of ethanol-induced liver injury”. Am. J. Physiol. Gastrointest. Liver Physiol. 307 (1): G58–65. doi:10.1152/ajpgi.00373.2013. PMC 4080163. PMID 24833709.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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