
Health Dictionary
Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
SH2D2A
Introduction
SH2 domain-containing protein 2A is a protein that in humans is encoded by the SH2D2A gene.[1][2]
References
References
- ↑ Spurkland A; Brinchmann JE; Markussen G; Pedeutour F; Munthe E; Lea T; Vartdal F; Aasheim HC (March 1998). “Molecular cloning of a T cell-specific adapter protein (TSAd) containing an Src homology (SH) 2 domain and putative SH3 and phosphotyrosine binding sites”. J Biol Chem. 273 (8): 4539–46. doi:10.1074/jbc.273.8.4539. PMID 9468509.
- ↑ “Entrez Gene: SH2D2A SH2 domain protein 2A”.
- ↑ Sun, W; Kesavan K; Schaefer B C; Garrington T P; Ware M; Johnson N L; Gelfand E W; Johnson G L (February 2001). “MEKK2 associates with the adapter protein Lad/RIBP and regulates the MEK5-BMK1/ERK5 pathway”. J. Biol. Chem. United States. 276 (7): 5093–100. doi:10.1074/jbc.M003719200. ISSN 0021-9258. PMID 11073940.
Further reading
Further reading
- Marti F; Lapinski PE; King PD (2005). “The emerging role of the T cell-specific adaptor (TSAd) protein as an autoimmune disease-regulator in mouse and man”. Immunol. Lett. 97 (2): 165–70. doi:10.1016/j.imlet.2004.10.019. PMID 15752554.
- Maruyama K; Sugano S (1994). “Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides”. Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). “Construction and characterization of a full length-enriched and a 5′-end-enriched cDNA library”. Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- Choi YB; Kim CK; Yun Y (1999). “Lad, an adapter protein interacting with the SH2 domain of p56lck, is required for T cell activation”. J. Immunol. 163 (10): 5242–9. PMID 10553045.
- Rajagopal K, Sommers CL, Decker DC, et al. (2000). “RIBP, a novel Rlk/Txk- and itk-binding adaptor protein that regulates T cell activation”. J. Exp. Med. 190 (11): 1657–68. doi:10.1084/jem.190.11.1657. PMC 2195727. PMID 10587356.
- Wu LW, Mayo LD, Dunbar JD, et al. (2000). “VRAP is an adaptor protein that binds KDR, a receptor for vascular endothelial cell growth factor”. J. Biol. Chem. 275 (9): 6059–62. doi:10.1074/jbc.275.9.6059. PMID 10692392.
- Dai KZ, Vergnaud G, Ando A, et al. (2000). “The SH2D2A gene encoding the T-cell-specific adapter protein (TSAd) is localized centromeric to the CD1 gene cluster on human Chromosome 1”. Immunogenetics. 51 (3): 179–85. doi:10.1007/s002510050029. PMID 10752626.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). “Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS…9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Smerdel A, Dai KZ, Lorentzen AR, et al. (2005). “Genetic association between juvenile rheumatoid arthritis and polymorphism in the SH2D2A gene”. Genes Immun. 5 (4): 310–2. doi:10.1038/sj.gene.6364093. PMID 15129233.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)”. Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Rush J, Moritz A, Lee KA, et al. (2005). “Immunoaffinity profiling of tyrosine phosphorylation in cancer cells”. Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455.
- Matsumoto T, Bohman S, Dixelius J, et al. (2005). “VEGF receptor-2 Y951 signaling and a role for the adapter molecule TSAd in tumor angiogenesis”. EMBO J. 24 (13): 2342–53. doi:10.1038/sj.emboj.7600709. PMC 1173150. PMID 15962004.
- Gregory SG, Barlow KF, McLay KE, et al. (2006). “The DNA sequence and biological annotation of human chromosome 1”. Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.
- Park D, Park I, Lee D, et al. (2007). “The adaptor protein Lad associates with the G protein beta subunit and mediates chemokine-dependent T-cell migration”. Blood. 109 (12): 5122–8. doi:10.1182/blood-2005-10-061838. PMID 17327418.
