
Health Dictionary
Reliable, easy-to-read patient information on common medical conditions β written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
SLC16A1
Introduction
Solute carrier family 16, member 1 (monocarboxylic acid transporter 1), also known as SLC16A1, is a human gene.[1]
References
References
Further reading
Further reading
- Bonen A (2002). “The expression of lactate transporters (MCT1 and MCT4) in heart and muscle”. Eur. J. Appl. Physiol. 86 (1): 6β11. PMIDΒ 11820324.
- Halestrap AP, Meredith D (2004). “The SLC16 gene family-from monocarboxylate transporters (MCTs) to aromatic amino acid transporters and beyond”. Pflugers Arch. 447 (5): 619β28. doi:10.1007/s00424-003-1067-2. PMIDΒ 12739169.
- Kim CM, Goldstein JL, Brown MS (1992). “cDNA cloning of MEV, a mutant protein that facilitates cellular uptake of mevalonate, and identification of the point mutation responsible for its gain of function”. J. Biol. Chem. 267 (32): 23113β21. PMIDΒ 1429658.
- Garcia CK, Li X, Luna J, Francke U (1995). “cDNA cloning of the human monocarboxylate transporter 1 and chromosomal localization of the SLC16A1 locus to 1p13.2-p12”. Genomics. 23 (2): 500β3. doi:10.1006/geno.1994.1532. PMIDΒ 7835905.
- Garcia CK, Goldstein JL, Pathak RK; et al. (1994). “Molecular characterization of a membrane transporter for lactate, pyruvate, and other monocarboxylates: implications for the Cori cycle”. Cell. 76 (5): 865β73. PMIDΒ 8124722.
- Bonaldo MF, Lennon G, Soares MB (1997). “Normalization and subtraction: two approaches to facilitate gene discovery”. Genome Res. 6 (9): 791β806. PMIDΒ 8889548.
- Ritzhaupt A, Wood IS, Ellis A; et al. (1999). “Identification and characterization of a monocarboxylate transporter (MCT1) in pig and human colon: its potential to transport L-lactate as well as butyrate”. J. Physiol. (Lond.). 513 ( Pt 3): 719β32. PMIDΒ 9824713.
- Rahman B, Schneider HP, BrΓΆer A; et al. (1999). “Helix 8 and helix 10 are involved in substrate recognition in the rat monocarboxylate transporter MCT1”. Biochemistry. 38 (35): 11577β84. doi:10.1021/bi990973f. PMIDΒ 10471310.
- Brooks GA, Brown MA, Butz CE; et al. (1999). “Cardiac and skeletal muscle mitochondria have a monocarboxylate transporter MCT1”. J. Appl. Physiol. 87 (5): 1713β8. PMIDΒ 10562613.
- Merezhinskaya N, Fishbein WN, Davis JI, Foellmer JW (2000). “Mutations in MCT1 cDNA in patients with symptomatic deficiency in lactate transport”. Muscle Nerve. 23 (1): 90β7. PMIDΒ 10590411.
- Kirk P, Wilson MC, Heddle C; et al. (2000). “CD147 is tightly associated with lactate transporters MCT1 and MCT4 and facilitates their cell surface expression”. EMBO J. 19 (15): 3896β904. doi:10.1093/emboj/19.15.3896. PMIDΒ 10921872.
- Cuff MA, Lambert DW, Shirazi-Beechey SP (2002). “Substrate-induced regulation of the human colonic monocarboxylate transporter, MCT1”. J. Physiol. (Lond.). 539 (Pt 2): 361β71. PMIDΒ 11882670.
- Cuff MA, Shirazi-Beechey SP (2002). “The human monocarboxylate transporter, MCT1: genomic organization and promoter analysis”. Biochem. Biophys. Res. Commun. 292 (4): 1048β56. doi:10.1006/bbrc.2002.6763. PMIDΒ 11944921.
- Lambert DW, Wood IS, Ellis A, Shirazi-Beechey SP (2002). “Molecular changes in the expression of human colonic nutrient transporters during the transition from normality to malignancy”. Br. J. Cancer. 86 (8): 1262β9. doi:10.1038/sj.bjc.6600264. PMIDΒ 11953883.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). “Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899β903. doi:10.1073/pnas.242603899. PMIDΒ 12477932.
- Zhang GZ, Huang GJ, Li WL; et al. (2002). “[Effect of co-inhibition of MCT1 gene and NHE1 gene on proliferation and growth of human lung adenocarcinoma cells]”. Ai Zheng. 21 (7): 719β23. PMIDΒ 12479094.
- Philp NJ, Wang D, Yoon H, Hjelmeland LM (2003). “Polarized expression of monocarboxylate transporters in human retinal pigment epithelium and ARPE-19 cells”. Invest. Ophthalmol. Vis. Sci. 44 (4): 1716β21. PMIDΒ 12657613.
- Asada K, Miyamoto K, Fukutomi T; et al. (2003). “Reduced expression of GNA11 and silencing of MCT1 in human breast cancers”. Oncology. 64 (4): 380β8. doi:10.1159/000070297. PMIDΒ 12759536.
