Health Dictionary
Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
SMC1B
Introduction
Structural maintenance of chromosomes protein 1B (SMC-1B) is a protein that in humans is encoded by the SMC1B gene.[1][2][3] SMC-1B belongs to a family of proteins required for chromatid cohesion and DNA recombination during meiosis and mitosis.[3] SMC1ß protein appears to participate with other cohesins REC8, STAG3 and SMC3 in sister-chromatid cohesion throughout the whole meiotic process in human oocytes.[4]
References
References
- ↑ “Entrez Gene: structural maintenance of chromosomes 1B”.
- ↑ Dunham I; Shimizu N; Roe BA; Chissoe S; Hunt AR; Collins JE; Bruskiewich R; Beare DM; Clamp M; Smink LJ; Ainscough R; Almeida JP; Babbage A; Bagguley C; Bailey J; Barlow K; Bates KN; Beasley O; Bird CP; Blakey S; Bridgeman AM; Buck D; Burgess J; Burrill WD; O’Brien KP (December 1999). “The DNA sequence of human chromosome 22”. Nature. 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208.
- ↑ 3.0 3.1 Revenkova E; Eijpe M; Heyting C; Gross B; Jessberger R (October 2001). “Novel meiosis-specific isoform of mammalian SMC1”. Mol. Cell. Biol. 21 (20): 6984–98. doi:10.1128/MCB.21.20.6984-6998.2001. PMC 99874. PMID 11564881.
- ↑ Garcia-Cruz R, Brieño MA, Roig I, Grossmann M, Velilla E, Pujol A, Cabero L, Pessarrodona A, Barbero JL, Garcia Caldés M (2010). “Dynamics of cohesin proteins REC8, STAG3, SMC1 beta and SMC3 are consistent with a role in sister chromatid cohesion during meiosis in human oocytes”. Hum. Reprod. 25 (9): 2316–27. doi:10.1093/humrep/deq180. PMID 20634189.
Further reading
Further reading
- Zhang X, Yang H, Lee JJ, et al. (2010). “MicroRNA-related genetic variations as predictors for risk of second primary tumor and/or recurrence in patients with early-stage head and neck cancer”. Carcinogenesis. 31 (12): 2118–23. doi:10.1093/carcin/bgq177. PMC 3105587. PMID 20819778.
- Cobbe N; Heck MM (2004). “The evolution of SMC proteins: phylogenetic analysis and structural implications”. Mol. Biol. Evol. 21 (2): 332–47. doi:10.1093/molbev/msh023. PMID 14660695.
- Prieto I, Tease C, Pezzi N, et al. (2004). “Cohesin component dynamics during meiotic prophase I in mammalian oocytes”. Chromosome Res. 12 (3): 197–213. doi:10.1023/B:CHRO.0000021945.83198.0e. PMID 15125634.
- Lee J; Iwai T; Yokota T; Yamashita M (2003). “Temporally and spatially selective loss of Rec8 protein from meiotic chromosomes during mammalian meiosis”. J. Cell Sci. 116 (Pt 13): 2781–90. doi:10.1242/jcs.00495. PMID 12759374.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2002). “Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Harrington JJ, Sherf B, Rundlett S, et al. (2001). “Creation of genome-wide protein expression libraries using random activation of gene expression”. Nat. Biotechnol. 19 (5): 440–5. doi:10.1038/88107. PMID 11329013.
- Barbe L, Lundberg E, Oksvold P, et al. (2008). “Toward a confocal subcellular atlas of the human proteome”. Mol. Cell. Proteomics. 7 (3): 499–508. doi:10.1074/mcp.M700325-MCP200. PMID 18029348.