SPHK2
Sphingosine kinase 2 is a protein that in humans is encoded by the SPHK2 gene.[1]
This gene encodes one of two sphingosine kinase isozymes that catalyze the phosphorylation of sphingosine into sphingosine 1-phosphate. Sphingosine 1-phosphate mediates many cellular processes including migration, proliferation and apoptosis, and also plays a role in several types of cancer by promoting angiogenesis and tumorigenesis. The encoded protein may play a role in breast cancer proliferation and chemoresistance. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2011].[1]
Further reading
Further reading
- Liu H, Sugiura M, Nava VE, Edsall LC, Kono K, Poulton S, Milstien S, Kohama T, Spiegel S (June 2000). “Molecular cloning and functional characterization of a novel mammalian sphingosine kinase type 2 isoform”. The Journal of Biological Chemistry. 275 (26): 19513–20. doi:10.1074/jbc.M002759200. PMID 10751414.
- Xia P, Wang L, Moretti PA, Albanese N, Chai F, Pitson SM, D’Andrea RJ, Gamble JR, Vadas MA (March 2002). “Sphingosine kinase interacts with TRAF2 and dissects tumor necrosis factor-alpha signaling”. The Journal of Biological Chemistry. 277 (10): 7996–8003. doi:10.1074/jbc.M111423200. PMC 3234989. PMID 11777919.
- Shu X, Wu W, Mosteller RD, Broek D (November 2002). “Sphingosine kinase mediates vascular endothelial growth factor-induced activation of ras and mitogen-activated protein kinases”. Molecular and Cellular Biology. 22 (22): 7758–68. doi:10.1128/mcb.22.22.7758-7768.2002. PMC 134718. PMID 12391145.
- Paugh SW, Payne SG, Barbour SE, Milstien S, Spiegel S (November 2003). “The immunosuppressant FTY720 is phosphorylated by sphingosine kinase type 2”. FEBS Letters. 554 (1–2): 189–93. doi:10.1016/S0014-5793(03)01168-2. PMID 14596938.
- Hait NC, Sarkar S, Le Stunff H, Mikami A, Maceyka M, Milstien S, Spiegel S (August 2005). “Role of sphingosine kinase 2 in cell migration toward epidermal growth factor”. The Journal of Biological Chemistry. 280 (33): 29462–9. doi:10.1074/jbc.M502922200. PMID 15951439.
- Okada T, Ding G, Sonoda H, Kajimoto T, Haga Y, Khosrowbeygi A, Gao S, Miwa N, Jahangeer S, Nakamura S (October 2005). “Involvement of N-terminal-extended form of sphingosine kinase 2 in serum-dependent regulation of cell proliferation and apoptosis”. The Journal of Biological Chemistry. 280 (43): 36318–25. doi:10.1074/jbc.M504507200. PMID 16103110.
- Olivera A, Urtz N, Mizugishi K, Yamashita Y, Gilfillan AM, Furumoto Y, Gu H, Proia RL, Baumruker T, Rivera J (February 2006). “IgE-dependent activation of sphingosine kinases 1 and 2 and secretion of sphingosine 1-phosphate requires Fyn kinase and contributes to mast cell responses”. The Journal of Biological Chemistry. 281 (5): 2515–25. doi:10.1074/jbc.M508931200. PMID 16316995.
- Sun J, Yan G, Ren A, You B, Liao JK (September 2006). “FHL2/SLIM3 decreases cardiomyocyte survival by inhibitory interaction with sphingosine kinase-1”. Circulation Research. 99 (5): 468–76. doi:10.1161/01.RES.0000239410.65551.b3. PMC 2614439. PMID 16888242.
- Hait NC, Bellamy A, Milstien S, Kordula T, Spiegel S (April 2007). “Sphingosine kinase type 2 activation by ERK-mediated phosphorylation”. The Journal of Biological Chemistry. 282 (16): 12058–65. doi:10.1074/jbc.M609559200. PMID 17311928.
- Ding G, Sonoda H, Yu H, Kajimoto T, Goparaju SK, Jahangeer S, Okada T, Nakamura S (September 2007). “Protein kinase D-mediated phosphorylation and nuclear export of sphingosine kinase 2”. The Journal of Biological Chemistry. 282 (37): 27493–502. doi:10.1074/jbc.M701641200. PMID 17635916.
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