Health Dictionary
Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
SPHK2
Introduction
Sphingosine kinase 2 is a protein that in humans is encoded by the SPHK2 gene.[1]
This gene encodes one of two sphingosine kinase isozymes that catalyze the phosphorylation of sphingosine into sphingosine 1-phosphate. Sphingosine 1-phosphate mediates many cellular processes including migration, proliferation and apoptosis, and also plays a role in several types of cancer by promoting angiogenesis and tumorigenesis. The encoded protein may play a role in breast cancer proliferation and chemoresistance. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2011].[1]
Further reading
Further reading
- Liu H, Sugiura M, Nava VE, Edsall LC, Kono K, Poulton S, Milstien S, Kohama T, Spiegel S (June 2000). “Molecular cloning and functional characterization of a novel mammalian sphingosine kinase type 2 isoform”. The Journal of Biological Chemistry. 275 (26): 19513–20. doi:10.1074/jbc.M002759200. PMID 10751414.
- Xia P, Wang L, Moretti PA, Albanese N, Chai F, Pitson SM, D’Andrea RJ, Gamble JR, Vadas MA (March 2002). “Sphingosine kinase interacts with TRAF2 and dissects tumor necrosis factor-alpha signaling”. The Journal of Biological Chemistry. 277 (10): 7996–8003. doi:10.1074/jbc.M111423200. PMC 3234989. PMID 11777919.
- Shu X, Wu W, Mosteller RD, Broek D (November 2002). “Sphingosine kinase mediates vascular endothelial growth factor-induced activation of ras and mitogen-activated protein kinases”. Molecular and Cellular Biology. 22 (22): 7758–68. doi:10.1128/mcb.22.22.7758-7768.2002. PMC 134718. PMID 12391145.
- Paugh SW, Payne SG, Barbour SE, Milstien S, Spiegel S (November 2003). “The immunosuppressant FTY720 is phosphorylated by sphingosine kinase type 2”. FEBS Letters. 554 (1–2): 189–93. doi:10.1016/S0014-5793(03)01168-2. PMID 14596938.
- Hait NC, Sarkar S, Le Stunff H, Mikami A, Maceyka M, Milstien S, Spiegel S (August 2005). “Role of sphingosine kinase 2 in cell migration toward epidermal growth factor”. The Journal of Biological Chemistry. 280 (33): 29462–9. doi:10.1074/jbc.M502922200. PMID 15951439.
- Okada T, Ding G, Sonoda H, Kajimoto T, Haga Y, Khosrowbeygi A, Gao S, Miwa N, Jahangeer S, Nakamura S (October 2005). “Involvement of N-terminal-extended form of sphingosine kinase 2 in serum-dependent regulation of cell proliferation and apoptosis”. The Journal of Biological Chemistry. 280 (43): 36318–25. doi:10.1074/jbc.M504507200. PMID 16103110.
- Olivera A, Urtz N, Mizugishi K, Yamashita Y, Gilfillan AM, Furumoto Y, Gu H, Proia RL, Baumruker T, Rivera J (February 2006). “IgE-dependent activation of sphingosine kinases 1 and 2 and secretion of sphingosine 1-phosphate requires Fyn kinase and contributes to mast cell responses”. The Journal of Biological Chemistry. 281 (5): 2515–25. doi:10.1074/jbc.M508931200. PMID 16316995.
- Sun J, Yan G, Ren A, You B, Liao JK (September 2006). “FHL2/SLIM3 decreases cardiomyocyte survival by inhibitory interaction with sphingosine kinase-1”. Circulation Research. 99 (5): 468–76. doi:10.1161/01.RES.0000239410.65551.b3. PMC 2614439. PMID 16888242.
- Hait NC, Bellamy A, Milstien S, Kordula T, Spiegel S (April 2007). “Sphingosine kinase type 2 activation by ERK-mediated phosphorylation”. The Journal of Biological Chemistry. 282 (16): 12058–65. doi:10.1074/jbc.M609559200. PMID 17311928.
- Ding G, Sonoda H, Yu H, Kajimoto T, Goparaju SK, Jahangeer S, Okada T, Nakamura S (September 2007). “Protein kinase D-mediated phosphorylation and nuclear export of sphingosine kinase 2”. The Journal of Biological Chemistry. 282 (37): 27493–502. doi:10.1074/jbc.M701641200. PMID 17635916.