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Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.

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SREBP cleavage activating protein

Introduction

SREBP cleavage-activating protein (SCAP) is regulatory protein that is required for the proteolytic cleavage of the sterol regulatory element binding protein (SREBP). SCAP is an integral membrane protein located in the endoplasmic reticulum (ER).^[1]

References

↑ Brown MS, Goldstein JL (1999). “A proteolytic pathway that controls the cholesterol content of membranes, cells, and blood”. Proc Natl Acad Sci U S A. 96 (20): 11041–8. PMID 10500120.

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