STEEPLE bleeding criteria

Safety and Efficacy Of Enoxaparin In Percutaneous Coronary Intervention Patients: An International Randomized Evaluation Major Bleeding

• Fatal bleeding
• Retroperitoneal, intracranial, or intraocular bleeding
• Bleeding that causes hemodynamic compromise requiring specific treatment
• Bleeding that requires intervention (surgical or endoscopic) or decompression of a closed space to stop or control the event
• Clinically overt bleeding, requiring any transfusion of ≥1 U PRBC or whole blood
• Clinically overt bleeding, causing a decrease in hemoglobin of ≥3 g/dL (or, if hemoglobin level is not available, a decrease in hematocrit of ≥10%)

Minor

• Gross hematuria not associated with trauma (eg, from instrumentation)
• Epistaxis that is prolonged, is repeated, or requires plugging or intervention
• Gastrointestinal hemorrhage
• Hemoptysis
• Subconjunctival hemorrhage
• Hematoma >5 cm or leading to prolonged or new hospitalization
• Clinically overt bleeding, causing a decrease in hemoglobin of 2 to 3 g/dL
• Uncontrolled bleeding requiring protamine sulfate administration