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Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.

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STK35L1

Introduction

STK35L1 is a protein that in humans is encoded by the STK35 (serine/threonine kinase 35) gene.[1] It is a member of the NKF4 (New Kinase Family 4) Ser/Thr kinases (STK) family and classified in group “Other” in the human kinome. Previously, STK35L1 was named as Clik1 (CLP36 Interacting Kinase 1) based on a study that showed an association of STK35 with CLP36 after overexpression of both proteins in osteosarcoma cells.[2][3] Clik1 gene described by Vallenius et al. code for a protein of 501 amino acids. Later, Goyal et al. found that coding sequence of the STK35 gene is incomplete. The newly identified sequence of the STK35 gene codes for a protein of 534 amino acids with a N-terminal elongation of 133 amino acids. It has been designated as STK35L1.

Functions

Functions

STK35L1 is predominantly found in the nucleus and the nucleolus. Nuclear actin was identified as a novel binding partner of STK35L1.[4] However, it can interact with PDLIM1/CLP-36 in the cytoplasm and localize to actin stress fibers. STK35L1 regulates the expression of CDKN2A and inhibiting G1- to S-phase transition.Depletion of STK35L1 by siRNA impaired endothelial cell migration. STK35L1 may act as a central kinase linking the cell cycle and migration of endothelial cells.

References

References

  1. ↑ “Entrez Gene: Serine/threonine kinase 35”. Retrieved 2012-02-18.
  2. ↑ Vallenius T, Mäkelä TP (May 2002). “Clik1: a novel kinase targeted to actin stress fibers by the CLP-36 PDZ-LIM protein”. Journal of Cell Science. 115 (Pt 10): 2067–73. PMID 11973348.
  3. ↑ Goyal P, Behring A, Kumar A, Siess W (2009-09-16). “Identifying and characterizing a novel protein kinase STK35L1 and deciphering its orthologs and close-homologs in vertebrates”. PLoS One. 4 (9): e6981. doi:10.1371/journal.pone.0006981. PMC 2737284. PMID 19756140.
  4. ↑ Goyal P, Behring A, Kumar A, Siess W (2011-01-20). “STK35L1 associates with nuclear actin and regulates cell cycle and migration of endothelial cells”. PLoS One. 6 (1): e16249. doi:10.1371/journal.pone.0016249. PMC 3024402. PMID 21283756.
Further reading

Further reading