Sarcoidosis other imaging findings

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: : Roshan Dinparasti Saleh M.D.

Overview

Radionuclide scanning, has been used in diagnosis of sarcoidosis and evaluation of organ involvement.

Other imaging findings

Radionuclide scanning, has been used in diagnosis of sarcoidosis and evaluation of organ involvement^[1]

Gallium scanning has been studied as a method for detection of inflammation^[2]^[3]. It also, can aid in identifying potential biopsy sites.

Lambda sign: radionuclide uptake in right paratracheal and bilateral hilar areas is highly supportive for diagnosis of sarcoidosis.
Panda sign: radionuclide uptake in parotid and lacrimal glands, is highly supportive for diagnosis of sarcoidosis^[4].

PET scan effectively shows disease activity in lungs, mediastinal lymph nodes, and other organs^[1]. The PET scan can aid in identifying potential sites for biopsy^[5]. In comparison with gallium scan, PET scan is more sensitive, reproducible, widely available, and can be performed in 1 day rather than 2 days necessary for gallium scan^[6].

References

↑ ^1.0 ^1.1 Keijsers RG, van den Heuvel DA, Grutters JC: Imaging the inlammatory activity of sarcoidosis. Eur Respir J 41(3):743–751, 2013.
↑ Keogh BA, Hunninghake GW, Line BR, Crystal RG: The alveolitis of pulmonary sarcoidosis: evaluation of natural history and alveolitisdependant changes in lung function. Am Rev Respir Dis 128:256–265, 1983.
↑ Baughman RP, Fernandez M, Bosken CH, et al: Comparison of gallium-67 scanning, bronchoalveolar lavage, and serum angiotensin-converting enzyme levels in pulmonary sarcoidosis. Predicting response to therapy. Am Rev Respir Dis 129:676–681, 1984.
↑ Sulavik SB, Spencer RP, Palestro CJ, et al: Speciicity and sensitivity of distinctive chest radiographic and/or 67Ga images in the noninvasive diagnosis of sarcoidosis. Chest 103:403–409, 1993.
↑ Teirstein AS, Machac J, Almeida O, et al: Results of 188 whole-body fluorodeoxyglucose positron emission tomography scans in 137 patients with sarcoidosis. Chest 132(6):1949–1953, 2007.
↑ Keijsers RG, Grutters JC, Thomeer M, et al: Imaging the inlammatory activity of sarcoidosis: sensitivity and inter observer agreement of (67)Ga imaging and (18)F-FDG PET. Q J Nucl Med Mol Imaging 55(1):66–71, 2011.

Overview