Schwartzman reaction

The Schwartzman Phenomenon (Schwartzman Reaction) occurs when a small dose of endotoxin is injected subcutaneously resulting in a mild inflammation. When a second dose of endotoxin is injected intravenously, the original skin site injection site becomes hemorrhagic within a few hours. This reaction cannot be explained on the basis of immunity and is probably essentially toxic in nature.

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