Health Dictionary
Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
Scleroderma future or investigational therapies
Introduction
Overview
Overview
Future or Investigational Therapies
Future or Investigational Therapies
Given the difficulty in treating scleroderma, treatments with a smaller evidence base are often tried to control the disease. These include antithymocyte globulin and mycophenolate mofetil; some reports have reported improvements in the skin symptoms as well as delaying the progress of systemic disease, but neither of them have been subjected to large clinical trials.[1]
While still experimental (given its high rate of complications), hematopoietic stem cell transplantation is being studied in patients with severe systemic sclerosis; improvement in life expectancy and severity of skin changes has been noted.[2]
References
References
- ↑ Zandman-Goddard G, Tweezer-Zaks N, Shoenfeld Y (2005). “New therapeutic strategies for systemic sclerosis–a critical analysis of the literature”. Clin. Dev. Immunol. 12 (3): 165–73. PMID 16295521. PMC 2275417
- ↑ Nash RA, McSweeney PA, Crofford LJ; et al. (2007). “High-dose immunosuppressive therapy and autologous hematopoietic cell transplantation for severe systemic sclerosis: long-term follow-up of the U.S. multicenter pilot study”. Blood. 110 (4): 1388–96. doi:10.1182/blood-2007-02-072389. PMID 17452515.
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]