Health Dictionary
Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
Scleroderma laboratory findings
Introduction
Overview
Overview
Specific laboratory findings consistent with the diagnosis of scleroderma include: Anti-Scl-70 antibody (Topoisomerase I), anti-centromere antibody (CREST syndrome), anti-nuclear antibody (ANA), anti-RNA polymerase III antibody, anti-U1-RNP antibody.
Laboratory Findings
Laboratory Findings
Laboratory findings consistent with the diagnosis of scleroderma include:[1]
- Anti-Scl-70 antibody (Topoisomerase I)
- Anti-centromere antibody (CREST syndrome)[2]
- Anti-nuclear antibody (ANA)
- Anti-RNA polymerase III antibody
- Anti-U1-RNP antibody
References
References
- ↑ Tan EM, Rodnan GP, Garcia I, Moroi Y, Fritzler MJ, Peebles C (June 1980). “Diversity of antinuclear antibodies in progressive systemic sclerosis. Anti-centromere antibody and its relationship to CREST syndrome”. Arthritis Rheum. 23 (6): 617–25. PMID 6155920.
- ↑ Powell FC, Winkelmann RK, Venencie-Lemarchand F, Spurbeck JL, Schroeter AL (October 1984). “The anticentromere antibody: disease specificity and clinical significance”. Mayo Clin. Proc. 59 (10): 700–6. PMID 6384675.
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: M. Khurram Afzal, MD [2]