Secondary amyloidosis laboratory findings
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sahar Memar Montazerin, M.D.[2] Shaghayegh Habibi, M.D.[3]
Overview
Overview
An elevated urinary protein is suggestive of secondary amyloidosis. Elevated level of acute phase reactant, abnormal liver function test, and other findings may also be observed.
Laboratory Findings
Laboratory Findings
- Laboratory findings suggestive of secondary amyloidosis vary depending on the affected organ.[1]
- The most commonly observable finding is proteinuria, particularly nephrotic range (>3.5 g/day).
- Other possible laboratory findings include:[2]
- Elevated NT-proBNP in case of cardiac involvement.
- Alkaline phosphatase Value >1.5 upper limit of normal in case of liver involvement.
- Elevated level of acute phase reactant due to underlying inflammatory condition.
References
References
- ↑ Papa, Riccardo; Lachmann, Helen J. (2018). “Secondary, AA, Amyloidosis”. Rheumatic Disease Clinics of North America. 44 (4): 585–603. doi:10.1016/j.rdc.2018.06.004. ISSN 0889-857X.
- ↑ Real de Asua, Diego; Galvan, Jose Maria; Filigghedu, Maria Teresa; Trujillo, Davinia; Costa, Ramon; Cadinanos, Julen (2014). “Systemic AA amyloidosis: epidemiology, diagnosis, and management”. Clinical Epidemiology: 369. doi:10.2147/CLEP.S39981. ISSN 1179-1349.
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