Secondary amyloidosis other diagnostic studies
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Shaghayegh Habibi, M.D.[2]
Overview
Overview
A tissue biopsy or fat aspirate should be done to confirm the presence or type of amyloid protein which is involved in the pathogenesis of the disease.
Other Diagnostic Studies
Other Diagnostic Studies
- A tissue biopsy or fat aspirate should be done to confirm the presence or type of amyloid protein which is involved in the pathogenesis of the disease.[1]
- To obtain a sample for histologic examination, multiple anatomical places have been used so far.
- In 1960s, gingival and mucosa biopsy were the anatomic places of choice, but they were now replaced by other more accessible places.
- Table below compares the recommended anatomical places.[2]
- It is of particular note that, a negative biopsy result for amyloid deposition would not exclude the diagnosis of amyloidosis, especially in the presence of high clinical suspicion.
| Test | Sensitivity | Specificity |
|---|---|---|
| Subcutaneous abdominal fat tissue aspiration | 57%–82% | 93%–100% |
| Rectal mucosa biopsy | 75%–85% | _ |
| Minor salivary gland biopsy | 83%–100% | _ |
References
References
- ↑ Mahmood S, Palladini G, Sanchorawala V, Wechalekar A (February 2014). “Update on treatment of light chain amyloidosis”. Haematologica. 99 (2): 209–21. doi:10.3324/haematol.2013.087619. PMC 3912950. PMID 24497558.
- ↑ Real de Asua, Diego; Galvan, Jose Maria; Filigghedu, Maria Teresa; Trujillo, Davinia; Costa, Ramon; Cadinanos, Julen (2014). “Systemic AA amyloidosis: epidemiology, diagnosis, and management”. Clinical Epidemiology: 369. doi:10.2147/CLEP.S39981. ISSN 1179-1349.
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