Health Dictionary
Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
Secondary amyloidosis other imaging findings
Introduction
Overview
Overview
Total body SAP component scintigraphy may be used in the workup and follow-up of patients with amyloid deposition. This method has been observed to have high sensitivity (90%) and requires a low radioactive dose which makes it a safe and effective method. The radiolabeled SAP binds to aa amyloid and localizes its deposition semiquantitatively.
Other Imaging Findings
Other Imaging Findings
Total Body SAP Scintigraphy
- Total body SAP component scintigraphy may be used in the workup and follow-up of patients with amyloid deposition.[1][2]
- This method has been observed to have high sensitivity (90%) and requires a low radioactive dose which makes its usage safe and effective.
- The radio labeled SAP binds to aa amyloid and localizes its deposition semi quantitatively.[3]
- However, this imaging modality is unable to identify deposits in hollow, diffuse, or small structures, such as the gastrointestinal tract, skin, and nerves.
- Also, SAP scintigraphy is unable to detect cardiac and lung involvement due to movement and blood content of these organs.
- Given the rarity of cardiac involvement in aa amyloidosis, an staging systems using cardiac imaging or biomarkers is not validated for detection of aa amyloid deposition in heart.
- Additionally, uremic cardiomyopathy is not distinguishable from amyloid deposition and cardiac magnetic resonance is relatively contraindicated in patients with secondary amyloidosis due to advanced renal disease.
References
References
- ↑ Hawkins, Philip N. (2002). “Serum amyloid P component scintigraphy for diagnosis and monitoring amyloidosis”. Current Opinion in Nephrology and Hypertension. 11 (6): 649–655. doi:10.1097/00041552-200211000-00013. ISSN 1062-4821.
- ↑ Hazenberg, Bouke P.C.; van Rijswijk, Martin H.; Piers, D. Albertus; Lub-de Hooge, Marjolijn N.; Vellenga, Edo; Haagsma, Elizabeth B.; Hawkins, Philip N.; Jager, Pieter L. (2006). “Diagnostic Performance of 123I-Labeled Serum Amyloid P Component Scintigraphy in Patients with Amyloidosis”. The American Journal of Medicine. 119 (4): 355.e15–355.e24. doi:10.1016/j.amjmed.2005.08.043. ISSN 0002-9343.
- ↑ Papa, Riccardo; Lachmann, Helen J. (2018). “Secondary, AA, Amyloidosis”. Rheumatic Disease Clinics of North America. 44 (4): 585–603. doi:10.1016/j.rdc.2018.06.004. ISSN 0889-857X.
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Shyam Patel [2]Associate Editor(s)-in-Chief: Sahar Memar Montazerin, M.D.[3]