Selenium deficiency
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:
Overview
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:
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Overview
Selenium deficiency is relatively rare in healthy well-nourished individuals. Few cases in humans have been reported.
Historical Perspective
Classification
Pathophysiology
Causes
Differentiating Selenium Deficiency from Other Diseases
Epidemiology and Demographics
Risk Factors
Screening
Natural History, Complications, and Prognosis
Diagnosis
Diagnostic Criteria
History and Symptoms
Physical Examination
Laboratory Findings
Imaging Findings
Other Diagnostic Studies
Treatment
Medical Therapy
Surgery
Prevention
References
Historical Perspective
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:
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Overview
Historical Perspective
References
Classification
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:
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Overview
Classification
References
Pathophysiology
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:
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Overview
Pathophysiology
References
Causes
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:
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Overview
Selenium deficiency is relatively rare in healthy well-nourished individuals. Few cases in humans have been reported.
Causes
It can occur in patients with severely compromised intestinal function, those undergoing total parenteral nutrition, those who have had gastrointestinal bypass surgery, and also in persons of advanced age (i.e., over 90).[1]
People dependent on food grown from selenium-deficient soil may be at risk for deficiency.
For some time now, it has been reported in medical literature that a pattern of side-effects possibly associated with cholesterol-lowering drugs (e.g., statins) may resemble the pathology of selenium deficiency.[2][3]
References
- ↑ Ravaglia, Giovanni; Forti, Paola; Maioli, Fabiola; Bastagli, Luciana; Facchini, Andrea; Mariani, Erminia; Savarino, Lucia; Sassi, Simonetta; et al. (2000). “Effect of micronutrient status on natural killer cell immune function in healthy free-living subjects aged ≥90 y”. American Journal of Clinical Nutrition. 71 (2): 590–8. PMID 10648276.
- ↑ Moosmann, B; Behl, C (2004). “Selenoprotein synthesis and side-effects of statins”. Lancet. 363 (9412): 892–4. doi:10.1016/S0140-6736(04)15739-5. PMID 15031036.
- ↑ Moosmann, B; Behl, C (2004). “Selenoproteins, cholesterol-lowering drugs, and the consequences: Revisiting of the mevalonate pathway”. Trends in Cardiovascular Medicine. 14 (7): 273–81. doi:10.1016/j.tcm.2004.08.003. PMID 15542379.
Differentiating Any Disease from other Diseases
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:
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Overview
Differential Diagnosis
References
Epidemiology and Demographics
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:
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Overview
Selenium deficiency is relatively rare in healthy well-nourished individuals. Few cases in humans have been reported.
Epidemiology and prevention
These diseases are most common in certain parts of China where the intake is low[1] because the soil is extremely deficient in selenium. Studies in Jiangsu Province of China have indicated a reduction in the prevalence of these diseases by taking selenium supplements.[2] In Finland, selenium salts are added to chemical fertilizers, as a way to increase selenium in soils.[3]
References
- ↑ “Selenium: Mineral Deficiency and Toxicity: Merck Manual Professional”. Retrieved 2008-11-29.
- ↑ “Dietary Supplement Fact Sheet: Selenium — Health Professional Fact Sheet”. ods.od.nih.gov. Retrieved 2015-09-08.
- ↑ Varo, Pertti; Alfihan, Georg; Ekholm, Paivi; Aro, Antti; Koivistoinen, Pekka (1988). “Selenium intake and serum selenium in Finland: effects of soil fertilization with selenium” (PDF). American Journal of Clinical Nutrition. Retrieved 8 September 2015.
Risk Factors
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:
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Overview
Risk Factors
References
Screening
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:
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Overview
Screening
References
Natural History, Complications and Prognosis
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:
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Overview
Natural History, Complications, and Prognosis
References
Diagnosis
Diagnosis
History and Symptoms | Physical Examination | Laboratory Findings | Electrocardiogram | X Ray | CT | MRI | Echocardiography or Ultrasound | Other Imaging Findings | Other Diagnostic Studies
Treatment
Treatment
Medical Therapy | Surgery | Primary Prevention | Secondary Prevention | Cost-Effectiveness of Therapy | Future or Investigational Therapies
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