Health Dictionary
Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
Sialidase
Introduction
Sialidase, accession number PF02973 is a widespread enzyme that catalyzes the hydrolysis of terminal acylneuraminic residues from oligosaccharides, glycolipids and glycoproteins. Also called neuraminidase.
It is present as a surface antigen in myxo viruses, hence sialidase inhibitors are used in anti-viral drugs.[1]
Deficiency of this enzyme, an autosomal recessive trait, causes sialidosis; enzyme activity is also lacking in galactosialidosis. The EC nomenclature is exo-α-sialidase.
References
References
- ↑ 1: Mol Gen Genet. 1991 Apr;226(1-2):190-7. The sialidase gene from Clostridium septicum: cloning, sequencing, expression in Escherichia coli and identification of conserved sequences in sialidases and other proteins Rothe B, Rothe B, Roggentin P, Schauer R.; Biochemisches Institut, Christian-Albrechts-Universitat zu Kiel, FRG.
External links
External links
- Sialidase at the US National Library of Medicine Medical Subject Headings (MeSH)
- EC 3.2.1.18