Sick sinus syndrome historical perspective

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sahar Memar Montazerin, M.D.[2]

Overview

Sick sinus syndrome was first discribed by Dr. Keith and Dr. Flack, in 1907. In 2015, MYH6 gene mutations were first implicated in the pathogenesis of sick sinus syndrome. In 1972, Dr. Mandel found a new method of assessing sinus node function, known as sinus node recovery time.

Historical Perspective

Discovery

Sick sinus syndrome was first discribed by Dr. Keith and Dr. Flack, in 1907.^[1]
In 2015, MYH6 gene mutations were first implicated in the pathogenesis of sick sinus syndrome.^[2]

Landmark Events in the Development of Treatment Strategies

In 1972, Dr. Mandel found a new method of assessing sinus node function, known as sinus node recovery time.^[3]

Impact on Cultural History

References

↑ Keith A, Flack M (April 1907). “The Form and Nature of the Muscular Connections between the Primary Divisions of the Vertebrate Heart”. J Anat Physiol. 41 (Pt 3): 172–89. PMC 1289112. PMID 17232727.
↑ Ishikawa T, Jou CJ, Nogami A, Kowase S, Arrington CB, Barnett SM, Harrell DT, Arimura T, Tsuji Y, Kimura A, Makita N (April 2015). “Novel mutation in the α-myosin heavy chain gene is associated with sick sinus syndrome”. Circ Arrhythm Electrophysiol. 8 (2): 400–8. doi:10.1161/CIRCEP.114.002534. PMID 25717017.
↑ Mandel, William J.; Hayakawa, Hirokazu; Allen, Howard N.; Danzig, Ronald; Kermaier, Alan I. (1972). “Assessment of Sinus Node Function in Patients with the Sick Sinus Syndrome”. Circulation. 46 (4): 761–769. doi:10.1161/01.CIR.46.4.761. ISSN 0009-7322.

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[pmid17232727-1] Keith A, Flack M (April 1907). “The Form and Nature of the Muscular Connections between the Primary Divisions of the Vertebrate Heart”. J Anat Physiol. 41 (Pt 3): 172–89. PMC 1289112. PMID 17232727.

[pmid25717017-2] Ishikawa T, Jou CJ, Nogami A, Kowase S, Arrington CB, Barnett SM, Harrell DT, Arimura T, Tsuji Y, Kimura A, Makita N (April 2015). “Novel mutation in the α-myosin heavy chain gene is associated with sick sinus syndrome”. Circ Arrhythm Electrophysiol. 8 (2): 400–8. doi:10.1161/CIRCEP.114.002534. PMID 25717017.

[MandelHayakawa1972-3] Mandel, William J.; Hayakawa, Hirokazu; Allen, Howard N.; Danzig, Ronald; Kermaier, Alan I. (1972). “Assessment of Sinus Node Function in Patients with the Sick Sinus Syndrome”. Circulation. 46 (4): 761–769. doi:10.1161/01.CIR.46.4.761. ISSN 0009-7322.

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