Sickle-cell disease history and symptoms

Symptoms of sickle-cell disease include mild pain in the arms an legs to severe pain from sickle cell crises and acute chest syndrome.

The most common symptoms of sickl cell disease are bone pain, numbness and tingling.

The location of vaso-occlusive episodes determines the types of symptoms a patient will experience. For example, vaso-occlusive crisis in the bones will cause bone pain. Bones, especially weight-bearing bones, are a common target of vaso-occlusive damage due to bone ischemia.

Common symptoms of sickle cell disease include:^[1][2][3]

• Pain and/or bone pain
• Dactylitis
• Blurry vision
• Persistent and painful erection
• Numbness
• Tingling
• Motor skill loss
• Speech deficits
• Gait disturbance
• Leg ulceration
• Jaundice

Symptoms of acute chest crisis include:^[4][5]

• Fever
• Chest pain
• Labored breathing
• Fatigue
• Shortness of breath
• Pallor