Sideroblastic anemia causes

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Nazia Fuad M.D.

Overview

There are no life-threatening causes of sideroblastic anemia, however complications resulting from untreated sideroblastic anemia is common.Common causes of sideroblastic anemia may include, alcoholism, chloramphenicol, isoniazid, copper deficiency (nutritional, zinc-induced, copper chelation), vit B-6 deficiency, X-linked sideroblastic anemia. Less common causes of sideroblastic anemia include myelodysplastic syndrome, autosomal recessive disorders, X-linked sideroblastic anemia. defect in ALAS2, autosomal recessive sideroblastic anemia with mutations in the SLC25A38 gene and genetic syndromes.

Causes

Life-threatening Causes

There are no life-threatening causes of sideroblastic anemia, however complications resulting from untreated sideroblastic anemia are common.

Common Causes

Common causes of sideroblastic anemia may include:^[1]^[2]

Alcoholism
Chloramphenicol
Isoniazid
Copper deficiency (nutritional, zinc-induced, copper chelation)
Vit B-6 deficiency
X-linked sideroblastic anemia

Less Common Causes

Less common causes of sideroblastic anemia include:

Genetic Causes

X-linked sideroblastic anemia. defect in ALAS2.^[3]
Autosomal recessive sideroblastic anemia with mutations in the SLC25A38 gene.
Genetic syndromes

Causes by Organ System

Cardiovascular	No underlying causes
Chemical/Poisoning	Lead poisoning, zinc
Dental	No underlying causes
Dermatologic	No underlying causes
Drug Side Effect	Chloramphenicol,Isoniazid cycloserine, linezolid,
Ear Nose Throat	No underlying causes
Endocrine	No underlying causes
Environmental	No underlying causes
Gastroenterologic	No underlying causes
Genetic	X-linked sideroblastic anemia. Autosomal recessive sideroblastic . Genetic syndromes
Hematologic	Myelodysplastic syndrome
Iatrogenic	No underlying causes
Infectious Disease	No underlying causes
Musculoskeletal/Orthopedic	No underlying causes
Neurologic	No underlying causes
Nutritional/Metabolic	Vit B-6 deficiency
Obstetric/Gynecologic	No underlying causes
Oncologic	No underlying causes
Ophthalmologic	No underlying causes
Overdose/Toxicity	Alcohol
Psychiatric	No underlying causes
Pulmonary	No underlying causes
Renal/Electrolyte	No underlying causes
Rheumatology/Immunology/Allergy	No underlying causes
Sexual	No underlying causes
Trauma	No underlying causes
Urologic	No underlying causes
Miscellaneous	No underlying causes

Causes in Alphabetical Order

List the causes of the disease in alphabetical order:

Alcohol
Vit B-6 def
Chloromphenicol
Copper deficiency
Cause 5
Cause 6
Cause 7
Cause 8
isoniazid
Cause 10

Toxins: lead or zinc poisoning

Drug-induced: Cycloserine, ethanol, isoniazid, chloramphenicol, cycloserine, Penicillamine

Nutritional: pyridoxine or copper deficiency

Genetic: ALA synthase deficiency (X-linked)

References

↑ Cazzola M, Invernizzi R (June 2011). “Ring sideroblasts and sideroblastic anemias”. Haematologica. 96 (6): 789–92. doi:10.3324/haematol.2011.044628. PMC 3105636. PMID 21632840.
↑ Bottomley SS, Fleming MD (August 2014). “Sideroblastic anemia: diagnosis and management”. Hematol. Oncol. Clin. North Am. 28 (4): 653–70, v. doi:10.1016/j.hoc.2014.04.008. PMID 25064706.
↑ Long Z, Li H, Du Y, Han B (August 2018). “Congenital sideroblastic anemia: Advances in gene mutations and pathophysiology”. Gene. 668: 182–189. doi:10.1016/j.gene.2018.05.074. PMID 29787825.

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[pmid21632840-1] Cazzola M, Invernizzi R (June 2011). “Ring sideroblasts and sideroblastic anemias”. Haematologica. 96 (6): 789–92. doi:10.3324/haematol.2011.044628. PMC 3105636. PMID 21632840.

[pmid25064706-2] Bottomley SS, Fleming MD (August 2014). “Sideroblastic anemia: diagnosis and management”. Hematol. Oncol. Clin. North Am. 28 (4): 653–70, v. doi:10.1016/j.hoc.2014.04.008. PMID 25064706.

[pmid29787825-3] Long Z, Li H, Du Y, Han B (August 2018). “Congenital sideroblastic anemia: Advances in gene mutations and pathophysiology”. Gene. 668: 182–189. doi:10.1016/j.gene.2018.05.074. PMID 29787825.

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