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Health Dictionary

Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.

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Sinusoidal obstruction syndrome classification

Introduction

Overview

Overview

There is no established system for the classification of sinusoidal obstruction syndrome. However, it can be classified on the basis of severity as mild, moderate and severe.

Classification

Classification

There is no established system for the classification of sinusoidal obstruction syndrome. However, it can be classified on the basis of severity as mild, moderate and severe.[1]

Parameters Mild Moderate Severe
Serum total bilirubin
  • <5 mg/dL
  • < (5.1 to 8 mg/dL
  • >8 mg/dL
Serum aspartate aminotransferase (AST)
  • <3 x normal
  • 3 to 8 x normal
  • >8 x normal
Weight above baseline
  • <2 percent
  • 2 to 5 percent
  • >5 percent
Serum creatinine
  • Normal
  • <2 x normal
  • >2 x normal
Rate of change Slow (over 6–7 d) (over 4–5 d) Rapid (over2–3 d)
References

References

  1. ↑ Chao N (2014). “How I treat sinusoidal obstruction syndrome”. Blood. 123 (26): 4023–6. doi:10.1182/blood-2014-03-551630. PMID 24833355.

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Husnain Shaukat, M.D [2]