Health Dictionary
Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
Sinusoidal obstruction syndrome history and symptoms
Introduction
Overview
Overview
Patients with sinusoidal obstruction syndrome may have a positive history of hematopoietic cell transplantation (HCT) or preexisting liver disease. Common symptoms of sinusoidal obstruction syndrome include tender hepatomegaly, weight gain and ascites.
History and Symptoms
History and Symptoms
History
Patients with sinusoidal obstruction syndrome may have a positive history of:[1][2][3]
- Hematopoietic cell transplantation (HCT)
- Preexisting liver disease
- Chemotherapeutic agents in non-transplant settings
- Liver transplantation
- High dose radiation therapy
Common Symptoms
Common symptoms of sinusoidal obstruction syndrome include:[1][4][4]
- Tender hepatomegaly
- Weight gain
- Ascites
- Abdominal pain or distention
- Jaundice
- Nausea and vomiting
- Anorexia
References
References
- ↑ 1.0 1.1 McDonald GB, Hinds MS, Fisher LD, Schoch HG, Wolford JL, Banaji M, Hardin BJ, Shulman HM, Clift RA (1993). “Veno-occlusive disease of the liver and multiorgan failure after bone marrow transplantation: a cohort study of 355 patients”. Ann. Intern. Med. 118 (4): 255–67. PMID 8420443.
- ↑ Bearman SI (1995). “The syndrome of hepatic veno-occlusive disease after marrow transplantation”. Blood. 85 (11): 3005–20. PMID 7756636.
- ↑ Richardson P, Guinan E (1999). “The pathology, diagnosis, and treatment of hepatic veno-occlusive disease: current status and novel approaches”. Br. J. Haematol. 107 (3): 485–93. PMID 10583247.
- ↑ 4.0 4.1 Zager RA (1994). “Acute renal failure in the setting of bone marrow transplantation”. Kidney Int. 46 (5): 1443–58. PMID 7853806.
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Husnain Shaukat, M.D [2]