Health Dictionary
Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
Sinusoidal obstruction syndrome primary prevention
Introduction
Overview
Overview
Primary preventive measures of sinusoidal obstruction syndrome include minimizing risks related to the transplant process such as the source of the graft (allogeneic greater than autologous), choice of chemotherapy and use of antimicrobials. The exposure to the hepatotoxic agents should be minimized and preexisting liver diseases should be managed. The prophylaxis for graft vs host disease should be considered.
Primary Prevention
Primary Prevention
Hepatic sinusoidal obstruction syndrome (SOS) is a complication of allogeneic and autologous hematopoietic cell transplantation (HCT). The measures for the primary prevention of sinusoidal obstruction syndrome include:[1][2]
- Minimizing risks related to the transplant process such as younger age < 7 years, source of the graft (allogeneic greater than autologous), choice of chemotherapy and use of antimicrobials.
- The exposure to the hepatotoxic agents should be minimized. This includes alcohol, over-the-counter medications (nonsteroidal anti-inflammatory drugs, overuse of acetaminophen), herbal remedies and prescribed drugs with hepatotoxic side effects.
- Treatment of preexisting liver disease.
- The prophylaxis for graft vs host disease should be considered.
References
References
- ↑ Dignan FL, Wynn RF, Hadzic N, Karani J, Quaglia A, Pagliuca A, Veys P, Potter MN (2013). “BCSH/BSBMT guideline: diagnosis and management of veno-occlusive disease (sinusoidal obstruction syndrome) following haematopoietic stem cell transplantation”. Br. J. Haematol. 163 (4): 444–57. doi:10.1111/bjh.12558. PMID 24102514.
- ↑ Ruutu T, Eriksson B, Remes K, Juvonen E, Volin L, Remberger M, Parkkali T, Hägglund H, Ringdén O (2002). “Ursodeoxycholic acid for the prevention of hepatic complications in allogeneic stem cell transplantation”. Blood. 100 (6): 1977–83. doi:10.1182/blood-2001-12-0159. PMID 12200355.
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Husnain Shaukat, M.D [2]