Sinusoidal obstruction syndrome risk factors

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Husnain Shaukat, M.D [2]

Overview

Common risk factors in the development of sinusoidal obstruction syndrome are stem cell transplantation, preexisting liver dysfunction and high-dose conditioning regimens.

Risk Factors

Common risk factors for sinusoidal obstruction syndrome are:^[1]^[2]^[3]

Stem cell transplantation
Preexisting liver dysfunction (elevated transaminases, fibrosis or cirrhosis, low albumin level pretransplantation)
Presence of hepatic metastases
Advanced age
Prior radiation treatment of the liver
High-dose conditioning regimens
Allogeneic transplantation (compared with autologous transplantation)
High dose radiation therapy
Liver transplantation

References

↑ Kumar S, DeLeve LD, Kamath PS, Tefferi A (2003). “Hepatic veno-occlusive disease (sinusoidal obstruction syndrome) after hematopoietic stem cell transplantation”. Mayo Clin Proc. 78 (5): 589–98. doi:10.4065/78.5.589. PMID 12744547.
↑ McDonald GB, Hinds MS, Fisher LD, Schoch HG, Wolford JL, Banaji M, Hardin BJ, Shulman HM, Clift RA (1993). “Veno-occlusive disease of the liver and multiorgan failure after bone marrow transplantation: a cohort study of 355 patients”. Ann. Intern. Med. 118 (4): 255–67. PMID 8420443.
↑ Carreras E, Bertz H, Arcese W, Vernant JP, Tomás JF, Hagglund H, Bandini G, Esperou H, Russell J, de la Rubia J, Di Girolamo G, Demuynck H, Hartmann O, Clausen J, Ruutu T, Leblond V, Iriondo A, Bosi A, Ben-Bassat I, Koza V, Gratwohl A, Apperley JF (1998). “Incidence and outcome of hepatic veno-occlusive disease after blood or marrow transplantation: a prospective cohort study of the European Group for Blood and Marrow Transplantation. European Group for Blood and Marrow Transplantation Chronic Leukemia Working Party”. Blood. 92 (10): 3599–604. PMID 9808553.

Overview