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Health Dictionary

Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.

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Sjögren's syndrome historical perspective

Introduction

Overview

Overview

In 1892, Johann von Mikulicz-Radecki was to first to describe a patient with with enlargement of the parotid and lacrimal glands associated with a round-cell infiltrate and acinar atrophy. In 1933, Henrik Sjögren was the first to describe 19 females with clinical and pathological manifestations of the Sjögren’s syndrome.

Historical Perspective

Historical Perspective

Discovery

  • In 1892, Johann von Mikulicz-Radecki was to first to describe a patient with enlargement of the parotid and lacrimal glands associated with a round-cell infiltrate and acinar atrophy.[1]
  • In 1933, Henrik Sjögren was the first to describe 19 females with clinical and pathological manifestations of the Sjögren’s syndrome.
  • In 1951, Sjögren published a paper describing 80 patients with keratoconjunctivitis sicca associated with Sjögren’s syndrome.
  • In 1976, the first symposium on Sjogren’s syndrome was held in Sweden.[2]
  • In 1980, autoantibodies to the centromere proteins (CENP) were found in 40% of patients with Sjögren’s syndrome.[3]
References

References

  1. ↑ Talal N (August 1992). “Sjögren’s syndrome: historical overview and clinical spectrum of disease”. Rheum. Dis. Clin. North Am. 18 (3): 507–15. PMID 1496158.
  2. ↑ Bjelle, A. (1987). “Historical Perspective: The Early Years (1930–1960)”: 3–6. doi:10.1007/978-3-642-50118-0_1.
  3. ↑ Fritzler, Marvin J.; Rattner, Jerome B.; Luft, LeeAnne M.; Edworthy, Steven M.; Casiano, Carlos A.; Peebles, Carol; Mahler, Michael (2011). “Historical perspectives on the discovery and elucidation of autoantibodies to centromere proteins (CENP) and the emerging importance of antibodies to CENP-F”. Autoimmunity Reviews. 10 (4): 194–200. doi:10.1016/j.autrev.2010.09.025. ISSN 1568-9972.

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Farima Kahe M.D. [2]