Health Dictionary
Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
Sodium-glucose co-transporter 2
Introduction
Overview
Overview
Sodium-dependent glucose cotrasporter 2 are a family of glucose transporter “expressed in the luminal membrane of the proximal kidney tubules“[1]. They contribute to renal glucose reabsorption.
Pharmacology
Pharmacology
Inhibitors
- Canagliflozin
- Dapagliflozin
- Empagliflozin
- Gliflozin
Inhibitors improve glycemic control[2] and may reduce clinical outcomes[3].
References
References
- ↑ Anonymous 2015, co-transporter 2 Sodium-glucose co-transporter 2. Medical Subject Headings. U.S. National Library of Medicine.
- ↑ Vasilakou D, Karagiannis T, Athanasiadou E, Mainou M, Liakos A, Bekiari E; et al. (2013). “Sodium-glucose cotransporter 2 inhibitors for type 2 diabetes: a systematic review and meta-analysis”. Ann Intern Med. 159 (4): 262–74. doi:10.7326/0003-4819-159-4-201308200-00007. PMID 24026259. Review in: Ann Intern Med. 2014 Jan 21;160(2):JC10
- ↑ Zinman B, Wanner C, Lachin JM, Fitchett D, Bluhmki E, Hantel S; et al. (2015). “Empagliflozin, Cardiovascular Outcomes, and Mortality in Type 2 Diabetes”. N Engl J Med. doi:10.1056/NEJMoa1504720. PMID 26378978.
External links
External links
- Sodium-Glucose+Transporter+2 at the US National Library of Medicine Medical Subject Headings (MeSH)