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Sp2 transcription factor
Introduction
Transcription factor Sp2 is a protein that in humans is encoded by the SP2 gene.[1][2][3]
Function
Function
This gene encodes a member of the Sp subfamily of Sp/XKLF transcription factors. Sp family proteins are sequence-specific DNA-binding proteins characterized by an amino-terminal trans-activation domain and three carboxy-terminal zinc finger motifs. This protein contains the least conserved DNA-binding domain within the Sp subfamily of proteins, and its DNA sequence specificity differs from the other Sp proteins. It localizes primarily within subnuclear foci associated with the nuclear matrix, and can activate or in some cases repress expression from different promoters.[3]
References
References
- â Kingsley C, Winoto A (Oct 1992). “Cloning of GT box-binding proteins: a novel Sp1 multigene family regulating T-cell receptor gene expression”. Mol Cell Biol. 12 (10): 4251â61. PMCÂ 360348. PMIDÂ 1341900.
- â Scohy S, Van Vooren P, Szpirer C, Szpirer J (Oct 1998). “Assignment1 of Sp genes to rat chromosome bands 7q36 (Sp1), 10q31âq32.1 (Sp2), 3q24âq31 (Sp3) and 6q33 (Sp4) and of the SP2 gene to human chromosome bands 17q21.3âq22 by in situ hybridization”. Cytogenet Cell Genet. 81 (3â4): 273â4. doi:10.1159/000015044. PMIDÂ 9730617.
- â 3.0 3.1 “Entrez Gene: SP2 Sp2 transcription factor”.
- â Rotheneder H, Geymayer S, Haidweger E (Nov 1999). “Transcription factors of the Sp1 family: interaction with E2F and regulation of the murine thymidine kinase promoter”. J. Mol. Biol. 293 (5): 1005â15. doi:10.1006/jmbi.1999.3213. PMIDÂ 10547281.
Further reading
Further reading
- Philipsen S, Suske G (1999). “A tale of three fingers: the family of mammalian Sp/XKLF transcription factors”. Nucleic Acids Res. 27 (15): 2991â3000. doi:10.1093/nar/27.15.2991. PMCÂ 148522. PMIDÂ 10454592.
- Nomura N, Nagase T, Miyajima N, Sazuka T, Tanaka A, Sato S, Seki N, Kawarabayasi Y, Ishikawa K, Tabata S (1995). “Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1”. DNA Res. 1 (5): 223â9. doi:10.1093/dnares/1.5.223. PMIDÂ 7584044.
- Rotheneder H, Geymayer S, Haidweger E (2000). “Transcription factors of the Sp1 family: interaction with E2F and regulation of the murine thymidine kinase promoter”. J. Mol. Biol. 293 (5): 1005â15. doi:10.1006/jmbi.1999.3213. PMIDÂ 10547281.
- Moorefield KS, Fry SJ, Horowitz JM (2004). “Sp2 DNA binding activity and trans-activation are negatively regulated in mammalian cells”. J. Biol. Chem. 279 (14): 13911â24. doi:10.1074/jbc.M313589200. PMIDÂ 14726517.
- Phan D, Cheng CJ, Galfione M, Vakar-Lopez F, Tunstead J, Thompson NE, Burgess RR, Najjar SM, Yu-Lee LY, Lin SH (2004). “Identification of Sp2 as a transcriptional repressor of carcinoembryonic antigen-related cell adhesion molecule 1 in tumorigenesis”. Cancer Res. 64 (9): 3072â8. doi:10.1158/0008-5472.CAN-03-3730. PMIDÂ 15126343.
- Phillips RJ, Tyson-Capper NÊe Pollard AJ, Bailey J, Robson SC, Europe-Finner GN (2005). “Regulation of expression of the chorionic gonadotropin/luteinizing hormone receptor gene in the human myometrium: involvement of specificity protein-1 (Sp1), Sp3, Sp4, Sp-like proteins, and histone deacetylases”. J. Clin. Endocrinol. Metab. 90 (6): 3479â90. doi:10.1210/jc.2004-1962. PMID 15788387.
- Lee YC, Higashi Y, Luu C, Shimizu C, Strott CA (2005). “Sp1 elements in SULT2B1b promoter and 5′-untranslated region of mRNA: Sp1/Sp2 induction and augmentation by histone deacetylase inhibition”. FEBS Lett. 579 (17): 3639â45. doi:10.1016/j.febslet.2005.05.041. PMIDÂ 15953604.
- Simmons SO, Horowitz JM (2006). “Nkx3.1 binds and negatively regulates the transcriptional activity of Sp-family members in prostate-derived cells”. Biochem. J. 393 (Pt 1): 397â409. doi:10.1042/BJ20051030. PMCÂ 1383699. PMIDÂ 16201967.
- Moorefield KS, Yin H, Nichols TD, Cathcart C, Simmons SO, Horowitz JM (2006). “Sp2 localizes to subnuclear foci associated with the nuclear matrix”. Mol. Biol. Cell. 17 (4): 1711â22. doi:10.1091/mbc.E05-11-1063. PMCÂ 1415311. PMIDÂ 16467376.
- Das A, Fernandez-Zapico ME, Cao S, Yao J, Fiorucci S, Hebbel RP, Urrutia R, Shah VH (2007). “Disruption of an SP2/KLF6 repression complex by SHP is required for farnesoid X receptor-induced endothelial cell migration”. J. Biol. Chem. 281 (51): 39105â13. doi:10.1074/jbc.M607720200. PMIDÂ 17071613.
External links
External links
- Sp2+Transcription+Factor at the US National Library of Medicine Medical Subject Headings (MeSH)
- FactorBook SP2