Developer site: The content shown here is test data.

MyEClinic
MyEClinic
Health Dictionary AI Health Chat Find an Online Doctor
A serene Zen garden with raked sand and smooth stones, symbolising clarity and calm

Health Dictionary

Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.

Back to skin conditions

Spondyloarthropathy risk factors

Introduction

Spondyloarthropathy risk factors

Since the role of genetic in the presence of spondyloarthropathies have been known since several years ago, genetically predisposing individuals are who have HLA-B27 gene, are at risk of developing spondyloarthropathies.

The risk of developing spondyloarthropathies in individuals with HLA-B27 gene is 1-2%, however, it can increase to 15-20% if he/she have a first-degree relative with positive HLA-B27 gene and developed spondyloarthropathy.

There some genes that are suspicious for their association in SpA, which are included:

  • HLA-B27
    • HLA-B*2702 (Association with AS)
    • HLA-B*2704 (Association with SpA)
    • HLA-B*2705 (Strong association with AS)
    • HLA-B*2706 (Very weak association with SpA)
    • HLA-B*2709 (AS sparing)
  • ERAP1
  • IL23R
  • TNFRSF1A
  • TRADD
  • TNFSF15
  • IL1A
  • IL1R2
  • CARD9
  • ANTXR2