Squamous cell carcinoma of the skin epidemiology and demographics

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Roukoz A. Karam, M.D.[2]

Overview

Cutaneous squamous cell carcinoma is the 2nd most common type of skin cancer in the United States. The incidence of squamous cell carcinoma of the skin increases dramatically with age. Cutaneous squamous cell carcinoma is a common disease that tends to affect people living closer to the equator.

Epidemiology and Demographics

Incidence

The exact incidence of squamous cell carcinoma of the skin is unknown since it is not included in the US national tumor registries.
The incidence of squamous cell carcinoma of the skin was estimated to be 9 to 96 cases per 100,000 male and 5 to 68 per 100,000 female individuals in Europe.^[1]
Cutaneous squamous cell carcinoma is the 2nd most common type of skin cancer in the United States, behind basal cell carcinoma (BCC).^[2]

Mortality rate

In the United States, the mortality rate of cutaneous squamous cell carcinoma is approximately 3932 to 8791.^[3]

Age

The incidence of squamous cell carcinoma of the skin increases with age.
Cutaneous squamous cell carcinoma infrequently affects people under the age of 45; however, the incidence in increasing in younger individuals.^[4]

For those over 75, the incidence is approximately 5 to 10 times higher than the incidence in younger age groups and 50 to 300 times higher than for those under 45.^[5]

Region

Cutaneous squamous cell carcinoma is a common disease that tends to affect people living closer to the equator.
- In Australia, for example, there are approximately 1035 and 472 cases per 100,000 for men and women, respectively.^[6]
- In contrast, the age-adjusted incidences for men and women in Finland are only about 6 and 4 per 100,000.^[7]

References

↑ Que SKT, Zwald FO, Schmults CD (2018). “Cutaneous squamous cell carcinoma: Incidence, risk factors, diagnosis, and staging”. J Am Acad Dermatol. 78 (2): 237–247. doi:10.1016/j.jaad.2017.08.059. PMID 29332704.
↑ Alam M, Ratner D (2001). “Cutaneous squamous-cell carcinoma”. N Engl J Med. 344 (13): 975–83. doi:10.1056/NEJM200103293441306. PMID 11274625.
↑ Karia, Pritesh S.; Han, Jiali; Schmults, Chrysalyne D. (2013). “Cutaneous squamous cell carcinoma: Estimated incidence of disease, nodal metastasis, and deaths from disease in the United States, 2012”. Journal of the American Academy of Dermatology. 68 (6): 957–966. doi:10.1016/j.jaad.2012.11.037. ISSN 0190-9622.
↑ Christenson LJ, Borrowman TA, Vachon CM, Tollefson MM, Otley CC, Weaver AL; et al. (2005). “Incidence of basal cell and squamous cell carcinomas in a population younger than 40 years”. JAMA. 294 (6): 681–90. doi:10.1001/jama.294.6.681. PMID 16091570.
↑ Gray DT, Suman VJ, Su WP, Clay RP, Harmsen WS, Roenigk RK (1997). “Trends in the population-based incidence of squamous cell carcinoma of the skin first diagnosed between 1984 and 1992”. Arch Dermatol. 133 (6): 735–40. PMID 9197827.
↑ Green A, Battistutta D, Hart V, Leslie D, Weedon D (1996). “Skin cancer in a subtropical Australian population: incidence and lack of association with occupation. The Nambour Study Group”. Am J Epidemiol. 144 (11): 1034–40. doi:10.1093/oxfordjournals.aje.a008875. PMID 8942434.
↑ Hannuksela-Svahn A, Pukkala E, Karvonen J (1999). “Basal cell skin carcinoma and other nonmelanoma skin cancers in Finland from 1956 through 1995”. Arch Dermatol. 135 (7): 781–6. PMID 10411152.

Template:WikiDoc Sources

[pmid29332704-1] Que SKT, Zwald FO, Schmults CD (2018). “Cutaneous squamous cell carcinoma: Incidence, risk factors, diagnosis, and staging”. J Am Acad Dermatol. 78 (2): 237–247. doi:10.1016/j.jaad.2017.08.059. PMID 29332704.

[pmid11274625-2] Alam M, Ratner D (2001). “Cutaneous squamous-cell carcinoma”. N Engl J Med. 344 (13): 975–83. doi:10.1056/NEJM200103293441306. PMID 11274625.

[KariaHan2013-3] Karia, Pritesh S.; Han, Jiali; Schmults, Chrysalyne D. (2013). “Cutaneous squamous cell carcinoma: Estimated incidence of disease, nodal metastasis, and deaths from disease in the United States, 2012”. Journal of the American Academy of Dermatology. 68 (6): 957–966. doi:10.1016/j.jaad.2012.11.037. ISSN 0190-9622.

[pmid16091570-4] Christenson LJ, Borrowman TA, Vachon CM, Tollefson MM, Otley CC, Weaver AL; et al. (2005). “Incidence of basal cell and squamous cell carcinomas in a population younger than 40 years”. JAMA. 294 (6): 681–90. doi:10.1001/jama.294.6.681. PMID 16091570.

[pmid9197827-5] Gray DT, Suman VJ, Su WP, Clay RP, Harmsen WS, Roenigk RK (1997). “Trends in the population-based incidence of squamous cell carcinoma of the skin first diagnosed between 1984 and 1992”. Arch Dermatol. 133 (6): 735–40. PMID 9197827.

[pmid8942434-6] Green A, Battistutta D, Hart V, Leslie D, Weedon D (1996). “Skin cancer in a subtropical Australian population: incidence and lack of association with occupation. The Nambour Study Group”. Am J Epidemiol. 144 (11): 1034–40. doi:10.1093/oxfordjournals.aje.a008875. PMID 8942434.

[pmid10411152-7] Hannuksela-Svahn A, Pukkala E, Karvonen J (1999). “Basal cell skin carcinoma and other nonmelanoma skin cancers in Finland from 1956 through 1995”. Arch Dermatol. 135 (7): 781–6. PMID 10411152.

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