Stamulumab
Stamulumab (MYO-029[1]) is an experimental myostatin inhibiting drug developed by Wyeth Pharmaceuticals for the treatment of muscular dystrophy. MYO-029 was formulated and tested by Wyeth in Collegeville, PA.[2] Myostatin is a protein that inhibits the growth of muscle tissue, MYO-029 is a recombinant human antibody designed to bind to and inhibit the activity of myostatin.[3]
Stamulumab is a G1 immunoglobulin antibody which binds to myostatin and prevents it from binding to its target site, thus inhibiting the growth-limiting action of myostatin on muscle tissue. Research completed in 2002 found that Stamulumab might one day prove to be an effective treatment for Duchenne muscular dystrophy[4]
Phase 1 and 2 Trials
Phase 1 and 2 Trials
- Wyeth undertook a Phase 1 and 2 clinical trial in 2005 and 2006 of MY0-029. The multiple ascending does trial (36 patients per cohort) contained some measures of efficacy. The trial’s participants included people afflicted with Facioscapulohumeral muscular dystrophy, Becker’s muscular dystrophy, and Limb-girdle muscular dystrophy. Through 2007 Wyeth has been analyzing the results and there is hope for news and/or a publication by the fourth quarter of 2007. [2][5][6]
Related
Related
References
References
- ↑ Wyeth Product Pipeline, Wyeth, Website accessed April 22, 2007
- ↑ 2.0 2.1 NIH‘s ClinicalTrials.gov, Study Evaluating MYO-029 in Adult Muscular Dystrophy, record last updated January 24, 2007
- ↑ medicalnewstoday.com, Wyeth Initiates Clinical Trial with Investigational Muscular Dystrophy Therapy MYO-029, Article Date: 28 Feb 2005 – 7:00 PDT
- ↑ Blocking Myostatin Proves Beneficial in Mice with DMD, MDA Research News, 11/27/2002
- ↑ Wyeth Analyzing MYO-029 Results, Muscular Dystrophy Association announcement, December 4, 2006
- ↑ FSH Watch Newsletter, pg 11, FSH Society, Summer 2007
- ↑ New Myostatin Blocker Makes Mouse Muscles 60 Percent Larger, MDA Research News, January 6, 2006
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