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Stibophen
Introduction
Overview
Overview
Stibophen is an anthelmintic classified as antimony compound and used as treatment of schistosomiasis[1] by intramuscular injection.
Mechanism of action
Mechanism of action
Stibophen inhibits the enzyme phosphofructokinase, which the worms need for glycolysis,[2] at least partly by binding to the sulfhydryl (–SH) group of the enzyme.[3] Inhibiting glycolysis paralyzes the worms, which lose their hold on the wall of mesenteric veins and undergo hepatic shift, die, and are phagocytosed by liver cells.
References
References
- ↑ PMID 13268811 (PMID 13268811)
Citation will be completed automatically in a few minutes. Jump the queue or expand by hand - ↑ PMID 13446367 (PMID 13446367)
Citation will be completed automatically in a few minutes. Jump the queue or expand by hand - ↑ PMID 8898332 (PMID 8898332)
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]