Stomach cancer classification

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];Associate Editor(s)-in-Chief: Omer Kamal, M.D.[2], Parminder Dhingra, M.D. [3], Mohammed Abdelwahed M.D [4]

Overview

Gastric cancer can be classified according to the Padova classification system based upon the grade of metaplasia, dysplasia and invasiveness of the disease. It may also be classified according to the Japanese classification system based on the type of lesions (benign or malignant) and atypia.

Classification

Gastric cancer can be classified according to the Padova classification system based upon the grade of metaplasia, dysplasia and invasiveness of the disease. It may also be classified according to the Japanese classification system based on the type of lesions (benign or malignant) and atypia. The following tables briefly outline the major classification systems:^[1]^[2]

1. Negative for dysplasia
1.0	Normal
1.1	Reactive foveolar hyperplasia
1.2	Intestinal metaplasia (IM)
1.2.1	IM Complete type
1.2.2	IM Incomplete type
2. Indefinite for dysplasia
2.1	Foveolar hyperproliferation
2.2	Hyperproliferative IM
3. Non-invasive neoplasia (flat or elevated [synonym adenoma])
3.1	Low-grade
3.2	High-grade
3.2.1	Including suspicious for carcinoma without invasion (interglandular)
3.2.2	Including carcinoma without invasion (intraglandular)
4. Suspicious for invasive carcinoma
5. Invasive adenocarcinoma

Category	Definition
Group I	Normal mucosa and benign lesions with no atypia
Group II	Lesions showing atypia but diagnosed as benign (non-neoplastic)
Group III	Borderline lesions between benign and malignant
Group V	Lesions strongly suspected of carcinoma
Group V	Carcinoma

References

Overview