Developer site: The content shown here is test data.

MyEClinic
MyEClinic
Health Dictionary AI Health Chat Find an Online Doctor
A serene Zen garden with raked sand and smooth stones, symbolising clarity and calm

Health Dictionary

Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.

Back to skin conditions

Streptomyces clavuligerus

Introduction

Streptomyces clavuligerus is a species of Gram positive bacterium that produces clavulanic acid.[1]

S. clavuligerus ATCC 27064 (NRRL 3585, DSM 738) was first described by Higgens and Kastner who isolated it from a South American soil sample.[2] Its name refers to the shape of its spore-bearing hyphal branches: clavula in Latin means little club and the suffix -igerus means bearing. S. clavuligerus spores are gray to grayish green.[2]

S. clavuligerus produces over 20 secondary metabolites, including many beta-lactam antibiotics such as clavulanic acid, cephamycin C, deacetoxycephalosporin C, penicillin N (an intermediate in cephamycin C pathway) and at least four other clavams.[3][4] Non-β-lactam antibiotics include holomycin and an antibiotic complex, MM 19290, related to tunicamycin;[5] a beta-lactamase-inhibitory protein (BLIP) has also been described.[6]

Another important characteristic of S. clavuligerus is that it is not able to use glucose as a carbon source, because it lacks a glucose transport system.[7][8]

It also possesses all the enzymes of the urea cycle, which is unusual for a prokaryote, although it is not clear if the urea cycle is functional.[9]

References

References

  1. ↑ Reading C, Cole M (1977). “Clavulanic acid: a beta-lactamase-inhiting beta-lactam from Streptomyces clavuligerus”. Antimicrob Agents Chemother. 11 (5): 852–7. PMID 879738.
  2. ↑ 2.0 2.1 Higgens CE, Kastner RE (1971). “Streptomyces clavuligerus sp. nov., a beta-lactam antibiotic producer”. International Journal of Systematic Bacteriology. 21: 326&ndash, 31.
  3. ↑ Nabais AMA, Dafonseca MMR (1995). “The Effect of Solid Medium Composition on Growth and Sporulation of Streptomyces-Clavuligerus – Spore Viability During Storage at +4-Degrees-C”. Biotechnology Techniques. 9: 361&ndash, 4.
  4. ↑ Tahlan K, Anders C, Jensen S (2004). “The paralogous pairs of genes involved in clavulanic acid and clavam metabolite biosynthesis are differently regulated in Streptomyces clavuligerus”. J Bacteriol. 186 (18): 6286–97. PMID 15342599.
  5. ↑ Baggaley K, Brown A, Schofield C (1997). “Chemistry and biosynthesis of clavulanic acid and other clavams”. Nat Prod Rep. 14 (4): 309–33. PMID 9281835.
  6. ↑ Doran J, Leskiw B, Aippersbach S, Jensen S (1990). “Isolation and characterization of a beta-lactamase-inhibitory protein from Streptomyces clavuligerus and cloning and analysis of the corresponding gene”. J Bacteriol. 172 (9): 4909–18. PMID 2203736.
  7. ↑ Aharonowitz Y, Demain A (1978). “Carbon catabolite regulation of cephalosporin production in Streptomyces clavuligerus”. Antimicrob Agents Chemother. 14 (2): 159–64. PMID 697343.
  8. ↑ Garcia-Dominguez M, Martin J, Liras P (1989). “Characterization of sugar uptake in wild-type Streptomyces clavuligerus, which is impaired in glucose uptake, and in a glucose-utilizing mutant”. J Bacteriol. 171 (12): 6808–14. PMID 2687256.
  9. ↑ Template:Cite paper
External links

Template:Bacteria-stub