Struma ovarii natural history, complications and prognosis

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:

Overview

If left untreated Struma ovarii may lead to thyrotoxicosis. Advanced disease may lead to malignancy, metastases, excessive hormone production and may prove fatal. The most feared complication of struma ovarii is thyrotoxicosis. Other complications include due to metastasis of struma oavrii. Prognosis is generally excellent under benign conditions and in malignant cases, adjuvant iodine-131 ablation with surgical extirpation has excellent prognosis. In adults with differentiated thyroid cancer who are treated with high doses of radioiodine seem to have an excellent long-term prognosis.

Natural History, Complications, and Prognosis

Natural History

If left untreated struma ovarii may lead to thyrotoxicosis. ^[1]
Advanced disease may lead to malignancy, metastases, excessive hormone production and may be fatal. ^[2]

Complications

One of struma ovarii complications is thyrotoxicosis. Other complication is metastasis of stroma ovarii in malignant types.^[3]

Prognosis

Prognosis is generally excellent in benign conditions. In malignant cases, adjuvant iodine-131 ablation with surgical excision has very good prognosis.
The 5, 10 and 20-years survival rate of patients with struma ovarii is approximately 96.7%, 94.3%, and 84.9%, respectively. ^[4]
In adults with differentiated thyroid cancer who are treated with high doses of radioiodine seem to have an excellent long-term prognosis. ^[5]

References

↑ Morrissey K, Winkel C, Hild S, Premkumar A, Stratton P (2007). “Struma ovarii coincident with Hashimoto’s thyroiditis: an unusual cause of hyperthyroidism”. Fertil. Steril. 88 (2): 497.e15–7. doi:10.1016/j.fertnstert.2006.11.095. PMC 2753978. PMID 17276434.
↑ Colomo Rodríguez, Natalia; Ruiz De Adana Navas, M. Soledad; González Romero, Stella; González Molero, Inmaculada; Reguera Iglesias, José M. (2011). “Leishmaniasis visceral en un paciente con diabetes tipo 1 y trasplante aislado de páncreas”. Endocrinología y Nutrición. 58 (7): 375–377. doi:10.1016/j.endonu.2011.02.004. ISSN 1575-0922.
↑ Matsuda K, Maehama T, Kanazawa K (2001). “Malignant struma ovarii with thyrotoxicosis”. Gynecol. Oncol. 82 (3): 575–7. doi:10.1006/gyno.2001.6315. PMID 11520159.
↑ Goffredo P, Sawka AM, Pura J, Adam MA, Roman SA, Sosa JA (2015). “Malignant struma ovarii: a population-level analysis of a large series of 68 patients”. Thyroid. 25 (2): 211–5. doi:10.1089/thy.2014.0328. PMID 25375817.
↑ Luo JR, Xie CB, Li ZH (2014). “Treatment for malignant struma ovarii in the eyes of thyroid surgeons: a case report and study of Chinese cases reported in the literature”. Medicine (Baltimore). 93 (26): e147. doi:10.1097/MD.0000000000000147. PMC 4616397. PMID 25474425.

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[pmid17276434-1] Morrissey K, Winkel C, Hild S, Premkumar A, Stratton P (2007). “Struma ovarii coincident with Hashimoto’s thyroiditis: an unusual cause of hyperthyroidism”. Fertil. Steril. 88 (2): 497.e15–7. doi:10.1016/j.fertnstert.2006.11.095. PMC 2753978. PMID 17276434.

[Colomo_RodríguezRuiz_De_Adana_Navas2011-2] Colomo Rodríguez, Natalia; Ruiz De Adana Navas, M. Soledad; González Romero, Stella; González Molero, Inmaculada; Reguera Iglesias, José M. (2011). “Leishmaniasis visceral en un paciente con diabetes tipo 1 y trasplante aislado de páncreas”. Endocrinología y Nutrición. 58 (7): 375–377. doi:10.1016/j.endonu.2011.02.004. ISSN 1575-0922.

[pmid11520159-3] Matsuda K, Maehama T, Kanazawa K (2001). “Malignant struma ovarii with thyrotoxicosis”. Gynecol. Oncol. 82 (3): 575–7. doi:10.1006/gyno.2001.6315. PMID 11520159.

[pmid25375817-4] Goffredo P, Sawka AM, Pura J, Adam MA, Roman SA, Sosa JA (2015). “Malignant struma ovarii: a population-level analysis of a large series of 68 patients”. Thyroid. 25 (2): 211–5. doi:10.1089/thy.2014.0328. PMID 25375817.

[pmid25474425-5] Luo JR, Xie CB, Li ZH (2014). “Treatment for malignant struma ovarii in the eyes of thyroid surgeons: a case report and study of Chinese cases reported in the literature”. Medicine (Baltimore). 93 (26): e147. doi:10.1097/MD.0000000000000147. PMC 4616397. PMID 25474425.

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