Health Dictionary
Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
Sulfadoxine
Introduction
Overview
Overview
Sulfadoxine (also spelled sulphadoxine) is an ultra-long-lasting sulfonamide previously used in combination with pyrimethamine to treat or prevent malaria.[1] Due to high levels of resistance, its use is no longer recommended routinely.[2] It is also used, usually in combination with other drugs, to treat or prevent various infections in livestock.[3]
It is on the World Health Organization’s List of Essential Medicines, a list of the most important medication needed in a basic health system.[4]
Mechanism of action
Mechanism of action
Sulfadoxine competitively inhibits dihydropteroate synthase, interfering with folate synthesis.
![700px U.S. Patent 3,132,139 BE 618639Â [5][6]](https://www.wikidoc.org/index.php/File%3ASulfadoxine_Syn.png)
References
References
- ↑ Medical Treatment – Sulphadoxine and Pyrimethamine.
- ↑ Matondo SI, Temba GS, Kavishe AA; et al. (2014). “High levels of sulphadoxine-pyrimethamine resistance Pfdhfr-Pfdhps quintuple mutations: a cross sectional survey of six regions in Tanzania”. Malar J. 13: 152. doi:10.1186/1475-2875-13-152. PMC 3998221. PMID 24751352.
- ↑ http://en.scientificcommons.org/19483411.
- ↑ “WHO Model List of EssentialMedicines” (PDF). World Health Organization. October 2013. Retrieved 22 April 2014.
- ↑ Template:Cite doi
- ↑ Template:Cite doi
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]