Developer site: The content shown here is test data.

MyEClinic
MyEClinic
Health Dictionary AI Health Chat Find an Online Doctor
A serene Zen garden with raked sand and smooth stones, symbolising clarity and calm

Health Dictionary

Reliable, easy-to-read patient information on common medical conditions β€” written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.

Back to skin conditions

Sulodexide

Introduction

Overview

Overview

Sulodexide is a highly purified mixture of glycosaminoglycans composed of low molecular weight heparin (80%) and dermatan sulfate (20%).

Pharmacology

Pharmacology

The low molecular weight of both sulodexide fractions allows for extensive oral absorption compared to unfractionated heparin. The pharmacological effects of sulodexide differ substantially from other glycosaminoglycans and are mainly characterized by a prolonged half-life and reduced effect on global coagulation and bleeding parameters.[1] Due to the presence of both glycosaminoglycan fractions, sulodexide potentiates the antiprotease activities of both antithrombin III and heparin cofactor II simultaneously.[2]

Uses

Uses

Clinically, sulodexide is used for the prophylaxis and treatment of thromboembolic diseases however recent research has also demonstrated the beneficial effects of sulodexide in animal models of reperfusion injury[3] and the treatment of diabetic nephropathy.[4][5][6] In combination with Melatonin, Sulodexide have been shown to be a viable treatment option for patients suffering from central or sensorineural tinnitus.[7][8]

References

References

  1. ↑ Lauver DA, Lucchesi BR (2006). “Sulodexide: a renewed interest in this glycosaminoglycan”. Cardio drug rev. 24 (3–4): 214–26. doi:10.1111/j.1527-3466.2006.00214.x. PMIDΒ 17214598.
  2. ↑ Harenberg J (1998). “Review of pharmacodynamics, pharmacokinetics, and therapeutic properties of sulodexide”. Med Res Rev. 18 (1): 1–20. doi:10.1002/(SICI)1098-1128(199801)18:1<1::AID-MED1>3.0.CO;2-4. PMIDΒ 9436179.
  3. ↑ Lauver DA, Booth EA, White AJ, Poradosu E, Lucchesi BR (2005). “Sulodexide attenuates myocardial ischemia/reperfusion injury and the deposition of C-reactive protein in areas of infarction without affecting hemostasis”. J Pharmacol Exp Ther. 312 (2): 794–800. doi:10.1124/jpet.104.075283. PMIDΒ 15365091.
  4. ↑ Achour A, Kacem M, Dibej K, Skhiri H, Bouraoui S, El May M. (2005). “One year course of oral sulodexide in the management of diabetic nephropathy”. J Nephrol. 18 (5): 568–574. PMIDΒ 16299683.
  5. ↑ Gambaro G, Venturini AP, Noonan DM; et al. (1994). “Treatment with a glycosaminoglycan formulation ameliorates experimental diabetic nephropathy”. Kidney Int. 46 (3): 797–806. doi:10.1038/ki.1994.335. PMIDΒ 7527876.
  6. ↑ Ε krhaa J, , J PeruΕ‘ičovΓ‘b J; et al. (1997). “Treatment with a glycosaminoglycan formulation ameliorates experimental diabetic nephropathy”. Diabetes Res Clin Practice. 38 (1): 25–31. doi:10.1016/S0168-8227(97)00076-4. PMIDΒ 9347243.
  7. ↑ Neri G, Baffa C, De Stefano A; et al. (2009). “Management of tinnitus: oral treatment with melatonin and sulodexide”. J. Biol. Regul. Homeost. Agents. 23 (2): 103–10. PMIDΒ 19589291.
  8. ↑ Neri G. De Stefano A. Baffa C. Kulamarva G. Di Giovanni P. Petrucci G. Poliandri A. Dispenza F. Citraro L. Croce A. ,”Treatment of central and sensorineural tinnitus with orally administered Melatonin and Sulodexide: personal experience from a randomized controlled study.” Acta Otorhinolaryngologica Italica. 29(2):86-91, 2009 Apr.

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]