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Swain equation
Introduction
The Swain equation relates the kinetic isotope effect for the proton/tritium combination with that of the proton/deuterium combination according to:
- <math>\frac{k_H}{k_T} = \frac{k_H}{k_D}^{1.442}</math>
where kH,D,T is the reaction rate constant for the protonated, deuterated and tritiated reactants.
References
References
- Use of Hydrogen Isotope Effects to Identify the Attacking Nucleophile in the Enolization of Ketones Catalyzed by Acetic Acid C. Gardner Swain, Edward C. Stivers, Joseph F. Reuwer, , Jr. Lawrence J. Schaad; J. Am. Chem. Soc.; 1958; 80(21); 5885-5893. First Page