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Health Dictionary

Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.

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Syndrome of inappropriate antidiuretic hormone laboratory findings

Introduction

Overview

Overview

Laboratory findings which are helpful in diagnosing syndrome of inappropriate antidiuretic hormone (SIADH) include serum electrolytes (especially sodium), blood urea nitrogen (BUN), creatinine, glucose levels, and osmolality. Laboratory findings in patients with SIADH may show hyponatremia (sodium <135 mEq/L) and low serum osmolality (< 280 mOsm/kg). Patients with SIADH have elevated urinary sodium level (> 20 mMol/L) and urine osmolality (generally > 100 mOsm/L). Patients with SIADH also have low BUN, normal creatinine, hypouricemia, and hypoalbuminemia.

Laboratory Findings

Laboratory Findings

Laboratory findings consistent with the diagnosis of SIADH include:[1][2][3][3][4][5]

References

References

  1. ↑ Shimamoto K, Murase T, Yamaji T (1976). “A heterologous radioimmunoassay for arginine vasopressin”. J. Lab. Clin. Med. 87 (2): 338–44. PMID 1245796.
  2. ↑ Laville M, Burst V, Peri A, Verbalis JG (2013). “Hyponatremia secondary to the syndrome of inappropriate secretion of antidiuretic hormone (SIADH): therapeutic decision-making in real-life cases”. Clin Kidney J. 6 (Suppl 1): i1–i20. doi:10.1093/ckj/sft113. PMC 4438352. PMID 26069838.
  3. ↑ 3.0 3.1 Peri A, Pirozzi N, Parenti G, Festuccia F, Menè P (2010). “Hyponatremia and the syndrome of inappropriate secretion of antidiuretic hormone (SIADH)”. J. Endocrinol. Invest. 33 (9): 671–82. doi:10.1007/BF03346668. PMID 20935451.
  4. ↑ Oh JY, Shin JI (2014). “Syndrome of inappropriate antidiuretic hormone secretion and cerebral/renal salt wasting syndrome: similarities and differences”. Front Pediatr. 2: 146. doi:10.3389/fped.2014.00146. PMC 4302789. PMID 25657991.
  5. ↑ Maesaka JK, Batuman V, Yudd M, Salem M, Sved AF, Venkatesan J (1990). “Hyponatremia and hypouricemia: differentiation from SIADH”. Clin. Nephrol. 33 (4): 174–8. PMID 2350904.

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Vindhya BellamKonda, M.B.B.S [2]