MRI scan is not diagnostic of syphilis. However, non-specific MRI findings may demonstrate complications of syphilis including neurological, gastrointestinal, and bone findings.^{[1][2][3][4][5][6][7][8][9][10][11][12]}

MRI scan is not diagnostic of syphilis. However, non-specific MRI findings may demonstrate complications of syphilis including neurological, gastrointestinal, and bone findings:^{[1][2][3][4][5][6][7][8][9][10][11]}

MRI may help diagnose complications of syphilis such as neurosyphilis. High intensity T2 MRI brain and spinal cord may indicate the following findings:^{[1][2][3][4][9]}

• Non specific white matter lesions (cerebral gummas or arteritis)^[2]
• Hyperintensity in mesiotemporal lobes^[4][5]
• Cortical atrophy (general paresis)^[1]
• Cerebral infarction
• Hippocampal atrophy (mimicking alzheimer’s disease)^[3]
• Hyperintensities in multiple cortical areas and thalami ^[7]
• Intramedullary hyperintensity and spinal cord atrophy^[12]

• Small tibial and fibular nodular hyperintense lesions^[13]

• T2W lesions in the skull showing hyperintensity^[10]

• T2W MRI images showing hyperintense thickening of rectal wall (mimicking rectal cancer)^[11]

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