Health Dictionary
Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
TCF15
Introduction
Transcription factor 15 is a protein that in humans is encoded by the TCF15 gene. [1]
Function
Function
The protein encoded by this gene is found in the nucleus and may be involved in the early transcriptional regulation of patterning of the mesoderm. The encoded basic helix-loop-helix protein requires dimerization with another basic helix-loop-helix protein for efficient DNA binding. [provided by RefSeq, Jul 2008].
Further reading
Further reading
- Guo P, Zhao KW, Dong XY, Sun X, Dong JT (2009). “Acetylation of KLF5 alters the assembly of p15 transcription factors in transforming growth factor-beta-mediated induction in epithelial cells”. J. Biol. Chem. 284 (27): 18184–93. doi:10.1074/jbc.M109.007096. PMC 2709394. PMID 19419955.
- Coppiello G, Collantes M, Sirerol-Piquer MS, Vandenwijngaert S, Schoors S, Swinnen M, Vandersmissen I, Herijgers P, Topal B, van Loon J, Goffin J, Prósper F, Carmeliet P, GarcÃa-Verdugo JM, Janssens S, Peñuelas I, Aranguren XL, Luttun A (2015). “Meox2/Tcf15 heterodimers program the heart capillary endothelium for cardiac fatty acid uptake”. Circulation. 131 (9): 815–26. doi:10.1161/CIRCULATIONAHA.114.013721. PMID 25561514.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.